{"id":"W2085297752","doi":"10.1074/jbc.m211813200","title":"The Methyl Donor S-Adenosylmethionine Inhibits Active Demethylation of DNA","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":181,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Deutsche Forschungsgemeinschaft; Faculty of Medicine, McGill University; McGill University","keywords":"Demethylase; Demethylation; Methyltransferase; DNA demethylation; Methylation; DNA methylation; Chemistry; Green fluorescent protein; HEK 293 cells; DNA; Molecular biology; Biochemistry; DNA methyltransferase; Transfection; Plasmid; Biology; Gene expression; Gene; Histone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002425379,0.0004254042,0.0004210777,0.0002166399,0.0001447527,0.0001946408,0.0002592257,0.0003201987,0.00137253],"category_scores_gemma":[0.0002352991,0.0001555266,0.0002263038,0.0001436032,0.0001888871,0.0001441687,0.0002163903,0.0004826974,0.0004633426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002242936,"about_ca_system_score_gemma":0.0003250522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005901435,"about_ca_topic_score_gemma":0.001017352,"domain_scores_codex":[0.9998216,0.00005026833,0.0000200458,0.00003066588,0.0000489923,0.00002842684],"domain_scores_gemma":[0.9998813,0.00003643972,0.00002121844,0.00001945625,0.00001334327,0.00002828687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001057473,0.00002449742,0.00009348286,0.00004704247,0.000006314624,0.00002348701,0.000005732033,0.00003287132,0.9976287,0.00007849751,0.00002752357,0.001926079],"study_design_scores_gemma":[0.0000153469,0.0003775735,0.0006531558,0.000003100346,0.000006687411,0.00007121723,0.00000390288,0.0002159547,0.9970095,0.00002132106,0.001620855,0.000001332009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791825,0.009338172,0.006782404,0.0002143934,0.00009714215,0.00008250104,0.0002977052,0.0001753537,0.003829876],"genre_scores_gemma":[0.9896427,0.002702313,0.004297894,0.00004157265,0.00002614266,0.00003945508,0.0003814479,0.00001488584,0.002853562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00137253,"threshold_uncertainty_score":0.004591525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02055385001244317,"score_gpt":0.2707104076636948,"score_spread":0.2501565576512516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}