{"id":"W2085297752","doi":"10.1074/jbc.m211813200","title":"The Methyl Donor S-Adenosylmethionine Inhibits Active Demethylation of DNA","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":181,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Deutsche Forschungsgemeinschaft; Faculty of Medicine, McGill University; McGill University","keywords":"Demethylase; Demethylation; Methyltransferase; DNA demethylation; Methylation; DNA methylation; Chemistry; Green fluorescent protein; HEK 293 cells; DNA; Molecular biology; Biochemistry; DNA methyltransferase; Transfection; Plasmid; Biology; Gene expression; Gene; Histone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001056599,0.0001301392,0.0002081248,0.00001744578,0.00008915806,0.0000141974,0.0001955482,0.0002759826,0.00003243634],"category_scores_gemma":[0.001885469,0.00007844722,0.0001883486,0.0001137834,0.0001458965,0.000004521948,0.00004333472,0.000209184,8.532998e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001993736,"about_ca_system_score_gemma":0.00009879638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":8.056451e-7,"about_ca_topic_score_gemma":7.41479e-7,"domain_scores_codex":[0.9987895,0.0001714584,0.0005246993,0.0001536709,0.000177841,0.0001827955],"domain_scores_gemma":[0.998602,0.0001592247,0.000614195,0.0001827785,0.000349929,0.0000918771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001303403,0.00005253299,0.001441178,0.000008576686,0.00006367905,8.453649e-7,0.00001428609,0.00006253089,0.9942673,0.00006668008,0.00004675859,0.003845259],"study_design_scores_gemma":[0.0003815585,0.0003059264,0.002060249,0.00001101386,0.00002074031,0.00001528595,0.00009217346,0.000003384913,0.9773251,0.001242322,0.01844764,0.00009459863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908097,0.005469471,0.001818824,0.0001188005,0.0001158268,0.00006079407,0.000005647904,0.000002181101,0.001598698],"genre_scores_gemma":[0.9960153,0.001971009,0.001608023,0.00002338275,0.0002205497,0.000002335776,0.00001138394,0.000008092655,0.0001398827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01840088,"threshold_uncertainty_score":0.3198985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02055385001244317,"score_gpt":0.2707104076636948,"score_spread":0.2501565576512516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}