{"id":"W2085303528","doi":"10.1371/journal.pone.0009934","title":"Tamoxifen Enhances the Hsp90 Molecular Chaperone ATPase Activity","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; University of Toronto; GlaxoSmithKline","keywords":"Hsp90; Tamoxifen; Chaperone (clinical); Metabolite; ATPase; Estrogen receptor; Biology; Drug discovery; Pharmacology; Chemistry; Biochemistry; Enzyme; Cancer; Medicine; Breast cancer; Heat shock protein; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001070786,0.0002146766,0.0002144816,0.0001665918,0.00007410026,0.0001889048,0.0001134146,0.0001584401,0.002792413],"category_scores_gemma":[0.0001886019,0.00005812363,0.0001819059,0.0001271376,0.00009540973,0.0001290113,0.0001491266,0.0002423054,0.0004915637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001591758,"about_ca_system_score_gemma":0.0001385793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003242067,"about_ca_topic_score_gemma":0.000572579,"domain_scores_codex":[0.9999235,0.00001380811,0.000006540216,0.00001039109,0.00002544867,0.00002034802],"domain_scores_gemma":[0.9999175,0.00002297337,0.00002150721,0.000006974356,0.0000163214,0.00001472667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002897999,0.00003154302,0.0002873086,0.00007782233,0.00001273564,0.00003999392,0.000006274493,0.00005988611,0.9930742,0.00004681787,0.0001220154,0.005951513],"study_design_scores_gemma":[0.00007907549,0.002205058,0.007327315,0.00001338276,0.00007715683,0.0004106796,0.00002593976,0.0005789857,0.9826681,0.00006670041,0.006541695,0.000005899489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890935,0.005273977,0.001757455,0.0002828339,0.00005774152,0.00003528356,0.0004164229,0.0001409317,0.002941793],"genre_scores_gemma":[0.9943802,0.00197358,0.000930461,0.00009017525,0.00001844226,0.00001652379,0.0003844552,0.00001081563,0.002195278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002792413,"threshold_uncertainty_score":0.009341598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02509998719309854,"score_gpt":0.2694948093759819,"score_spread":0.2443948221828833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}