{"id":"W2085310757","doi":"10.1128/aac.00314-07","title":"Effects of the Translocation Status of Human Immunodeficiency Virus Type 1 Reverse Transcriptase on the Efficiency of Excision of Tenofovir","year":2007,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; McGill University; Gilead Sciences","keywords":"Reverse transcriptase; Zidovudine; Nucleotide; Thymidine; Reverse-transcriptase inhibitor; Nucleotide excision repair; Biology; Tenofovir; Molecular biology; Virology; Nucleoside; DNA; Chemistry; Virus; RNA; Human immunodeficiency virus (HIV); Biochemistry; DNA damage; Viral disease; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005178304,0.0003933245,0.0003065416,0.0001159406,0.00009634723,0.0004916532,0.000278063,0.000365514,0.001274064],"category_scores_gemma":[0.001206764,0.0002322805,0.0001660507,0.0001476939,0.000287671,0.0004265599,0.0001928026,0.0004472423,0.0002921456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002317025,"about_ca_system_score_gemma":0.0001846254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006575519,"about_ca_topic_score_gemma":0.000450585,"domain_scores_codex":[0.9995306,0.0001754035,0.00005467268,0.00008341336,0.0000813799,0.00007459006],"domain_scores_gemma":[0.9991844,0.0004583251,0.0001220909,0.00006606094,0.00006193175,0.000107161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006744353,0.0001105225,0.0002994844,0.00003154873,0.000007499435,0.00004508909,0.000035311,0.0002362675,0.9966061,0.00007306652,0.00001976403,0.001860898],"study_design_scores_gemma":[0.00002847742,0.001398941,0.001920813,0.000007250243,0.00001300535,0.0001179633,0.0000330594,0.001728788,0.9941987,0.00002768216,0.0005152723,0.0000100373],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998447,0.0006218359,0.0003683104,0.00002562219,0.00001731609,0.000009313965,0.00005909529,0.00001419157,0.0004373792],"genre_scores_gemma":[0.9985304,0.0002662112,0.0005640967,0.00001388236,0.000004381708,0.000006937025,0.0001116849,0.00001090744,0.0004914511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001274064,"threshold_uncertainty_score":0.00426209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01224921166701914,"score_gpt":0.2630841846614157,"score_spread":0.2508349729943966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}