{"id":"W2085316849","doi":"10.1002/stem.447","title":"Decoded Calreticulin-Deficient Embryonic Stem Cell Transcriptome Resolves Latent Cardiophenotype","year":2010,"lang":"en","type":"article","venue":"Stem Cells","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Ted Nash Long Life Foundation; J. Willard and Alice S. Marriott Foundation; American Heart Association","keywords":"Calreticulin; Biology; Transcriptome; Induced pluripotent stem cell; Stem cell; Embryonic stem cell; Cell biology; Computational biology; Genetics; Gene; Endoplasmic reticulum; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001548219,0.0002883401,0.000262363,0.00004521337,0.0001237899,0.00006017959,0.000315917,0.0002362831,0.00006305183],"category_scores_gemma":[0.000002937218,0.0002521566,0.0002857193,0.0000936854,0.0001182532,0.000004375641,0.00008985836,0.0002251791,0.0001296199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001478653,"about_ca_system_score_gemma":0.0001181066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001941535,"about_ca_topic_score_gemma":0.00002852994,"domain_scores_codex":[0.9982841,0.00006955714,0.0002984873,0.0005976123,0.0002635745,0.000486672],"domain_scores_gemma":[0.9987539,0.00001593537,0.00009572412,0.0007220051,0.00009826534,0.000314193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009232761,0.0001171932,0.0007366536,0.00008136746,0.00003730857,0.00002337119,0.00009011741,0.0003243616,0.9958541,0.0001799978,0.001680521,0.0007826163],"study_design_scores_gemma":[0.0009881584,0.0001947106,0.0005357689,0.0000156942,0.00008372276,0.00001094524,0.0002074852,0.000154458,0.9605767,0.00001864255,0.03681033,0.0004034407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990943,0.001977389,0.0003093519,0.00007708825,0.001233315,0.0003197525,0.0001108683,0.00003677019,0.004992539],"genre_scores_gemma":[0.9949354,0.0002281017,0.0002071345,0.0001401426,0.0002040053,0.00003450345,0.00004833623,0.00004660519,0.004155763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03527752,"threshold_uncertainty_score":0.9999931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006634493160173841,"score_gpt":0.2095942809128206,"score_spread":0.2029597877526468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}