{"id":"W2085337384","doi":"10.2174/1568011013354705","title":"Modulation of P-Glycoprotein (PGP) Mediated Multidrug Resistance (MDR) Using Chemosensitizers: Recent Advances in the Design of Selective MDR Modulators","year":2001,"lang":"en","type":"review","venue":"Current Medicinal Chemistry - Anti-Cancer Agents","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Multiple drug resistance; P-glycoprotein; Pharmacology; Drug; Drug discovery; Drug resistance; Computational biology; Medicine; Biology; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009231312,0.0008541321,0.002989572,0.0002374454,0.00009493458,0.00001011432,0.0004968369,0.0004544875,0.000143822],"category_scores_gemma":[0.0001999655,0.0006036217,0.0004807359,0.001856524,0.0003641137,0.0001441582,0.00003924095,0.001052964,0.000001916569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000615378,"about_ca_system_score_gemma":0.0009439313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002516676,"about_ca_topic_score_gemma":0.000008701079,"domain_scores_codex":[0.9947768,0.0002352728,0.001885606,0.0009107093,0.001546444,0.000645134],"domain_scores_gemma":[0.9967166,0.0001643721,0.001755316,0.0007015358,0.0004623967,0.0001997645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001546765,0.002202827,0.0009264941,0.2054161,0.001070369,0.0003589263,0.002010466,0.001084737,0.01970959,0.000008546886,0.0004645802,0.7652006],"study_design_scores_gemma":[0.01097905,0.000253645,0.0009340663,0.3288911,0.008044022,0.0001817843,0.001348519,0.004817443,0.05056823,0.0001376654,0.5911649,0.002679589],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008381248,0.9863454,0.001816124,0.00003570756,0.0005199583,0.002516848,0.0001652841,0.00003613915,0.0001832707],"genre_scores_gemma":[0.02777652,0.9705413,0.0004189568,0.00001563159,0.0003808222,0.0001626534,0.0005162056,0.00008942305,0.00009848012],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.762521,"threshold_uncertainty_score":0.9996415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1004655284149344,"score_gpt":0.3843011175125655,"score_spread":0.2838355890976311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}