{"id":"W2085350682","doi":"10.1038/nature09830","title":"DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration","year":2011,"lang":"en","type":"article","venue":"Nature","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":614,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier de l'Université Laval; Université Laval","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Eye Institute; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Howard Hughes Medical Institute","keywords":"Alu element; microRNA; RNA; Gene knockdown; Macular degeneration; Biology; Downregulation and upregulation; Cell biology; RNA interference; Retinal degeneration; Retinal pigment epithelium; Cancer research; Retina; Genetics; Gene; Medicine; Human genome; Ophthalmology; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004781562,0.0005441289,0.0008508511,0.0009924585,0.0005128754,0.0005509463,0.0005704098,0.001098029,0.00368902],"category_scores_gemma":[0.0004491401,0.0005072199,0.0005993402,0.0003892835,0.0007900259,0.0006128892,0.0004625846,0.001369346,0.0007737855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007877733,"about_ca_system_score_gemma":0.0004801427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009219035,"about_ca_topic_score_gemma":0.001173212,"domain_scores_codex":[0.9993079,0.0001556399,0.0001245239,0.0001589493,0.0001207229,0.0001323514],"domain_scores_gemma":[0.9993735,0.0001289501,0.0001903254,0.0001055462,0.00004327107,0.000158387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000417975,0.00007258203,0.0001146207,0.00004694281,0.00001260784,0.0002710417,0.00002130835,0.00008986786,0.9974408,0.0002732663,0.0001028467,0.001136173],"study_design_scores_gemma":[0.0000795956,0.0004236975,0.003214813,0.000009200022,0.00004036256,0.0008495446,0.00006362616,0.001107453,0.9923706,0.0002745018,0.00155265,0.00001386863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99277,0.001507611,0.002369889,0.0003473576,0.0001299183,0.00004850566,0.0006409856,0.0001937118,0.001991954],"genre_scores_gemma":[0.9930547,0.000622143,0.001749832,0.0001260213,0.00002681578,0.00006470623,0.0002693736,0.00006435619,0.004021947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00368902,"threshold_uncertainty_score":0.01234102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01085720637023821,"score_gpt":0.2403046805883772,"score_spread":0.229447474218139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}