{"id":"W2085350682","doi":"10.1038/nature09830","title":"DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration","year":2011,"lang":"en","type":"article","venue":"Nature","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":614,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier de l'Université Laval; Université Laval","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Eye Institute; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Howard Hughes Medical Institute","keywords":"Alu element; microRNA; RNA; Gene knockdown; Macular degeneration; Biology; Downregulation and upregulation; Cell biology; RNA interference; Retinal degeneration; Retinal pigment epithelium; Cancer research; Retina; Genetics; Gene; Medicine; Human genome; Ophthalmology; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001160163,0.0001185212,0.00008876061,0.00005577778,0.00003740315,0.0000125784,0.0001295143,0.001205027,0.00006972511],"category_scores_gemma":[0.00005817036,0.0001152199,0.0000570122,0.0001292784,0.00003300947,0.00000601091,0.00004730922,0.0004298364,0.00001128974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002566367,"about_ca_system_score_gemma":0.00004046658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001927857,"about_ca_topic_score_gemma":0.0001014401,"domain_scores_codex":[0.9992489,0.00005957273,0.0001599786,0.0002698503,0.0001099637,0.0001517235],"domain_scores_gemma":[0.9996061,0.000002589632,0.00006421971,0.0002272109,0.00005156118,0.00004830254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003393225,0.00005854443,0.001777498,0.000008676779,0.00002216467,0.00001260714,0.00006433071,0.00004360057,0.9961538,0.0003203643,0.0005926001,0.0009118842],"study_design_scores_gemma":[0.000370989,0.00004110333,0.0630876,0.00001445882,0.00001693865,0.000006112479,0.0000149714,0.00006175379,0.9344753,0.0003957044,0.001350747,0.0001643276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947343,0.002564024,0.00007763892,0.00005226386,0.0001458776,0.0001596857,0.0000100459,0.00001521531,0.002240953],"genre_scores_gemma":[0.998551,0.00004316883,0.000589293,0.0002369233,0.00008949947,0.00001051688,0.000311527,0.00001662605,0.0001514589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06167851,"threshold_uncertainty_score":0.929427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01085720637023821,"score_gpt":0.2403046805883772,"score_spread":0.229447474218139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}