{"id":"W2085362274","doi":"10.4161/cc.5.13.2899","title":"γH2AX as a Checkpoint Maintenance Signal","year":2006,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Fault Detection and Control Systems","field":"Engineering","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Biology; G2-M DNA damage checkpoint; CHEK1; Cell biology; DNA damage; Cell cycle checkpoint; Genetics; Cancer; Cell cycle; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009610287,0.0003792457,0.000238897,0.0002882775,0.0002749287,0.0007275746,0.000394576,0.0004484772,0.00707966],"category_scores_gemma":[0.0001754066,0.0001176274,0.00008396144,0.0003494881,0.0004187665,0.0004556848,0.0003255504,0.0004099389,0.002769434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003727491,"about_ca_system_score_gemma":0.0001854555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002438782,"about_ca_topic_score_gemma":0.0002316106,"domain_scores_codex":[0.9999149,0.00001411095,0.000003562255,0.00002377353,0.00002906093,0.00001454377],"domain_scores_gemma":[0.9999198,0.00002042291,0.00001312285,0.00001280998,0.00001409858,0.00001980676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008595923,0.00008118252,0.0004383327,0.0003996921,0.00001100378,0.0008802195,0.0000669889,0.00421922,0.8936622,0.03108407,0.005029592,0.06326805],"study_design_scores_gemma":[0.00008266974,0.0003705365,0.002210856,0.00005730813,0.00001978898,0.001357165,0.00008816378,0.01797073,0.8685142,0.01658246,0.0927066,0.00003958337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5390742,0.02803265,0.2170287,0.008163078,0.003480424,0.0002199892,0.003202015,0.003886669,0.1969122],"genre_scores_gemma":[0.9432576,0.003603214,0.0173409,0.0003136582,0.0001638213,0.00004265997,0.0004180432,0.00006957784,0.0347905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00707966,"threshold_uncertainty_score":0.02368385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003966430297352375,"score_gpt":0.1804129230911161,"score_spread":0.1764464927937637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}