{"id":"W2085366875","doi":"10.1016/j.epidem.2012.10.001","title":"Pre-existence and emergence of drug resistance in a generalized model of intra-host viral dynamics","year":2012,"lang":"en","type":"article","venue":"Epidemics","topic":"Hepatitis C virus research","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Eidgenössische Technische Hochschule Zürich; European Commission","keywords":"Context (archaeology); Viral life cycle; Mutation rate; Biology; Population; Mutation; Drug resistance; Virology; Virus; Viral quasispecies; Host (biology); Human immunodeficiency virus (HIV); Resistance mutation; Viral replication; Hepatitis C virus; Genetics; Medicine; Gene; RNA; Reverse transcriptase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009393982,0.0009799523,0.00164958,0.0009018832,0.0008935768,0.001809332,0.001816347,0.002665972,0.003072701],"category_scores_gemma":[0.003166733,0.0007099095,0.001376499,0.0006307909,0.002450901,0.002077943,0.001640313,0.001376076,0.0005264836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001656782,"about_ca_system_score_gemma":0.001528203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0171152,"about_ca_topic_score_gemma":0.007879431,"domain_scores_codex":[0.9995909,0.0001603631,0.00001449636,0.0000656932,0.00005195422,0.0001165765],"domain_scores_gemma":[0.9989409,0.000480218,0.0002324512,0.00006584547,0.000105487,0.0001751342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00009174969,0.00005741653,0.001895187,0.00005264192,0.00005955384,0.0004469381,0.00023124,0.8944016,0.002941305,0.09694966,0.0008573465,0.002015404],"study_design_scores_gemma":[0.00003020489,0.00002933469,0.0002623975,0.000006024547,0.00001408161,0.0000396297,0.00002773108,0.9867254,0.00005922664,0.01251057,0.0002834638,0.00001191491],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6142709,0.001678723,0.3412381,0.004890658,0.0002030413,0.0001241883,0.0006237202,0.0004106438,0.03656012],"genre_scores_gemma":[0.9719107,0.0006933939,0.009202773,0.0003644348,0.00007411406,0.0001718908,0.0001620878,0.00007710179,0.01734341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0171152,"threshold_uncertainty_score":0.03403115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04566529432938569,"score_gpt":0.3487374414611694,"score_spread":0.3030721471317837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}