{"id":"W2085376606","doi":"10.1016/j.cmet.2009.03.013","title":"APPL1 Potentiates Insulin-Mediated Inhibition of Hepatic Glucose Production and Alleviates Diabetes via Akt Activation in Mice","year":2009,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":false,"ca_institutions":"York University","funders":"","keywords":"Protein kinase B; Insulin; Diabetes mellitus; Internal medicine; PI3K/AKT/mTOR pathway; Endocrinology; Proto-Oncogene Proteins c-akt; Medicine; Chemistry; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002833368,0.0002008204,0.0003017865,0.000135281,0.00004352769,0.0000176275,0.00008054747,0.0001672271,0.00001127464],"category_scores_gemma":[0.0001635688,0.0001954773,0.00006045094,0.0002324371,0.0000657116,0.00002649664,0.00003334562,0.0001044419,0.00000399577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009358821,"about_ca_system_score_gemma":0.00003302401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002673185,"about_ca_topic_score_gemma":0.00001351346,"domain_scores_codex":[0.9987243,0.0001118172,0.0003582677,0.0003979586,0.0001501972,0.0002574688],"domain_scores_gemma":[0.9993754,0.00001503982,0.0002112216,0.0002101745,0.0001221822,0.00006598256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000427302,0.0001666177,0.0007373226,0.00006677544,0.00001726152,1.828149e-7,0.0001164427,0.00003226858,0.9626257,0.00001519583,0.00009538702,0.03608415],"study_design_scores_gemma":[0.0007056039,0.00007617181,0.02093917,0.00003887646,0.00004763845,3.617002e-7,0.00004410482,0.00009342338,0.9732719,0.0006392929,0.003941248,0.0002022045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.877791,0.121478,0.0001106387,0.00005560023,0.0001846295,0.0002902518,0.000008736594,0.00001355668,0.0000676072],"genre_scores_gemma":[0.9730088,0.0258537,0.0003282357,0.0002339544,0.0002746635,0.00003337399,0.0002162941,0.00001877539,0.00003225403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09562426,"threshold_uncertainty_score":0.7971331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004210079752478614,"score_gpt":0.1963987307838808,"score_spread":0.1921886510314022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}