{"id":"W2085568870","doi":"10.1016/j.str.2006.03.003","title":"I Siah Substrate!","year":2006,"lang":"en","type":"letter","venue":"Structure","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Degron; Ubiquitin ligase; Ubiquitin-Protein Ligases; Ubiquitin; DNA ligase; Cell biology; Chemistry; Biology; Biophysics; Computational biology; Biochemistry; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.00003220234,0.0003479753,0.0002171476,0.00004110905,0.00006776481,0.00004784236,0.0003326646,0.001673504,0.0003651583],"category_scores_gemma":[0.00001004573,0.0003114208,0.0001541084,0.0000548147,0.00007598877,0.00000108366,0.00007327397,0.0009303365,0.00003602498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001153309,"about_ca_system_score_gemma":0.00009731951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001931194,"about_ca_topic_score_gemma":0.00002779456,"domain_scores_codex":[0.9986862,0.00005627591,0.0001806595,0.0005075798,0.0001876483,0.0003816173],"domain_scores_gemma":[0.9992495,0.000004850661,0.0001109684,0.0005395231,0.00005784373,0.00003735752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000005041896,0.000002062103,0.00008594133,0.00006917089,0.00003450094,0.00006693714,0.000004881219,0.000003438879,0.06804494,0.0000155168,0.9313346,0.0003330026],"study_design_scores_gemma":[0.0001539476,0.00005953366,0.0001603519,0.00001190626,0.00002032567,0.00004159055,0.000001684681,5.024413e-7,0.1408464,0.0007997879,0.8575695,0.0003344684],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.4128521,0.01047816,0.0002922483,0.4060743,0.005702417,0.002425888,0.009150584,0.0003176405,0.1527067],"genre_scores_gemma":[0.1443236,0.0000437515,0.001037985,0.7473264,0.03104165,0.00004320166,0.0300374,0.000245365,0.0459007],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.3412521,"threshold_uncertainty_score":0.9999338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007354333113989024,"score_gpt":0.2155821106078442,"score_spread":0.2082277774938552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}