{"id":"W2085640503","doi":"10.2174/187231207780363589","title":"Involvement of Cytochromes P450 2D6, 2B6 and 2C19 in the Metabolism of (-)-Deprenyl and N-Methyl,N-propargylphenylethylamine","year":2007,"lang":"en","type":"article","venue":"Drug Metabolism Letters","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"CYP2B6; Cytochrome P450; Microsome; Chemistry; Metabolism; Enzyme; CYP2C19; Monoamine oxidase B; CYP2D6; Drug metabolism; Monoamine oxidase; Biochemistry; Pharmacology; CYP1A2; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003011852,0.0003696629,0.0003260806,0.0004132131,0.000243282,0.0003745381,0.0001334883,0.0003439439,0.001228818],"category_scores_gemma":[0.0002962473,0.0002405729,0.0003231871,0.0002384255,0.0002311408,0.0002576603,0.00009440129,0.0003199439,0.0004479704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003260886,"about_ca_system_score_gemma":0.0002356462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001354354,"about_ca_topic_score_gemma":0.00212529,"domain_scores_codex":[0.9998318,0.00006058666,0.0000115437,0.00003886565,0.00003798843,0.000019117],"domain_scores_gemma":[0.9998432,0.00003113614,0.00005355353,0.00002117111,0.00002385522,0.00002707279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002104835,0.000124869,0.008331115,0.0001306336,0.0001252003,0.0005549468,0.00007985828,0.0003023879,0.9722309,0.0005109314,0.0001770673,0.01532744],"study_design_scores_gemma":[0.0001111832,0.000867286,0.06283814,0.000009971734,0.0001034753,0.002131141,0.00005779891,0.001660868,0.9282584,0.0004335677,0.003509466,0.00001870469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9696628,0.0117208,0.01284756,0.0003167924,0.00005678887,0.000161452,0.001666051,0.00008007369,0.003487834],"genre_scores_gemma":[0.9832336,0.003822629,0.008308777,0.00005754056,0.00003477545,0.00006810854,0.001534603,0.00002110918,0.002918911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001354354,"threshold_uncertainty_score":0.004110754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008003705292582772,"score_gpt":0.2209574830703426,"score_spread":0.2129537777777598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}