{"id":"W2085643863","doi":"10.1128/jvi.00006-15","title":"Soluble T Cell Immunoglobulin Mucin Domain 3 Is Shed from CD8 <sup>+</sup> T Cells by the Sheddase ADAM10, Is Increased in Plasma during Untreated HIV Infection, and Correlates with HIV Disease Progression","year":2015,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Maple Leaf Medical Clinic; St. Michael's Hospital; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Center for Research Resources; U.S. Public Health Service","keywords":"Biology; CD8; Immunology; Antibody; Cytotoxic T cell; T cell; Pathogenesis; Immune system; Virology; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001096358,0.000304171,0.0001873726,0.0001757411,0.0001210887,0.0003239627,0.0001397172,0.0002649311,0.002097478],"category_scores_gemma":[0.0002009411,0.00007624317,0.0001313324,0.0001495066,0.00021039,0.0001579457,0.00014673,0.0003636958,0.000428767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001872151,"about_ca_system_score_gemma":0.00009690393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002408644,"about_ca_topic_score_gemma":0.0001965419,"domain_scores_codex":[0.9998976,0.00001668861,0.00001132971,0.00002310948,0.0000252394,0.00002594894],"domain_scores_gemma":[0.9998326,0.00002322941,0.0000804551,0.000008675306,0.00002035475,0.0000346283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001748201,0.00008848829,0.02172228,0.0002155816,0.00003801731,0.0004259079,0.00006105217,0.00009132778,0.9603107,0.00004377126,0.0003140987,0.0149406],"study_design_scores_gemma":[0.0001045992,0.003642679,0.3764777,0.00006554678,0.0002252658,0.009244979,0.0002626331,0.001888455,0.6004492,0.0001780329,0.007439868,0.00002103389],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994552,0.003913938,0.000543994,0.00006521366,0.0000240161,0.00001096804,0.0003937965,0.00005425218,0.0004418946],"genre_scores_gemma":[0.9977646,0.0007119065,0.0003701217,0.00004000365,0.00002911896,0.00001504874,0.0004452238,0.000005691988,0.0006182417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002097478,"threshold_uncertainty_score":0.007016778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004491624673651065,"score_gpt":0.2024935433686552,"score_spread":0.1980019186950042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}