{"id":"W2085680350","doi":"10.1016/j.bcp.2004.06.022","title":"Geraniol and β-ionone inhibit proliferation, cell cycle progression, and cyclin-dependent kinase 2 activity in MCF-7 breast cancer cells independent of effects on HMG-CoA reductase activity","year":2004,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":168,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Cyclin-dependent kinase; Biology; HMG-CoA reductase; Geraniol; Cell growth; Cell cycle; MCF-7; Mevalonic acid; Kinase; Reductase; Cyclin; Mevalonate pathway; Cyclin E; Biochemistry; Cancer cell; Cell; Enzyme; Cancer; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00020859,0.0003066267,0.0003286599,0.00006663977,0.00007383657,0.00001445762,0.0001388309,0.0004239882,0.00001633265],"category_scores_gemma":[0.00002979507,0.0002793875,0.00005843563,0.000103255,0.0002111904,0.00001046273,0.0001853998,0.0002896749,0.000001600569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000662816,"about_ca_system_score_gemma":0.000139125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000515912,"about_ca_topic_score_gemma":0.000006254951,"domain_scores_codex":[0.9983615,0.0001321424,0.0002577162,0.0007136691,0.0001777634,0.0003571522],"domain_scores_gemma":[0.999299,0.00005395449,0.0001819383,0.0001873414,0.00006314529,0.0002146309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002178467,0.001111401,0.0006170706,0.0003144898,0.00004673464,0.0000328564,0.00002902592,0.00003349805,0.993453,0.000001506537,0.000733714,0.001448187],"study_design_scores_gemma":[0.002872508,0.0002624314,0.004223249,0.00009176724,0.00005554245,0.00004962956,0.00000725103,0.00002860786,0.9920467,0.00002293643,0.00003994735,0.0002994031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974267,0.0007552673,0.00001020529,0.0008046857,0.0001356125,0.0005694247,0.0002486939,0.00001440037,0.00003497594],"genre_scores_gemma":[0.9986987,0.0005316169,0.00008289234,0.0002326653,0.000266344,0.0001105262,0.00003572939,0.00002012967,0.00002137517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003606178,"threshold_uncertainty_score":0.9999658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00498436383906688,"score_gpt":0.2619574770317533,"score_spread":0.2569731131926865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}