{"id":"W2085697990","doi":"10.1002/jgm.1267","title":"The combination of stabilized plasmid lipid particles and lipid nanoparticle encapsulated CpG containing oligodeoxynucleotides as a systemic genetic vaccine","year":2008,"lang":"en","type":"article","venue":"The Journal of Gene Medicine","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arbutus Biopharma (Canada); University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Michael Smith Health Research BC","keywords":"CpG Oligodeoxynucleotide; Immune system; Systemic administration; Transfection; DNA vaccination; Antigen; Gene delivery; Transgene; Immunology; Genetic enhancement; Biology; In vivo; Gene; Immunization; Biotechnology; Gene expression; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008912366,0.0001302298,0.000280705,0.00004401112,0.0001792119,0.000007466472,0.0002516684,0.00005394977,0.0000150554],"category_scores_gemma":[0.000379354,0.00006857955,0.00005496205,0.0001058227,0.0002469345,0.000008747571,0.00005365492,0.0001073333,0.000002098046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001290769,"about_ca_system_score_gemma":0.0000850931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004380479,"about_ca_topic_score_gemma":0.000014958,"domain_scores_codex":[0.9985858,0.0002313714,0.0006426287,0.0001074459,0.0002454813,0.000187324],"domain_scores_gemma":[0.9986894,0.0001448815,0.0004682213,0.0002461598,0.0003655052,0.00008587331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001013228,0.00003729283,0.005258814,0.00001428602,0.0001210746,0.000009354991,0.0009750212,0.0002324963,0.9905494,0.00001431772,0.0005091236,0.001265613],"study_design_scores_gemma":[0.003462112,0.004387284,0.01306133,0.0001805439,0.0001784689,0.002262972,0.002102194,0.0009451777,0.9725154,0.0001397202,0.0006441441,0.0001206328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904652,0.007928487,0.0002349953,0.0009990603,0.0001937897,0.0001437409,0.000001404924,0.000003558038,0.00002979253],"genre_scores_gemma":[0.992474,0.006956722,0.00005407974,0.0001617197,0.0002823389,0.000003446734,0.000002498655,0.00001256063,0.00005261097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01803396,"threshold_uncertainty_score":0.2796593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01273255562458519,"score_gpt":0.2397753319293494,"score_spread":0.2270427763047642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}