{"id":"W2085697990","doi":"10.1002/jgm.1267","title":"The combination of stabilized plasmid lipid particles and lipid nanoparticle encapsulated CpG containing oligodeoxynucleotides as a systemic genetic vaccine","year":2008,"lang":"en","type":"article","venue":"The Journal of Gene Medicine","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arbutus Biopharma (Canada); University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Michael Smith Health Research BC","keywords":"CpG Oligodeoxynucleotide; Immune system; Systemic administration; Transfection; DNA vaccination; Antigen; Gene delivery; Transgene; Immunology; Genetic enhancement; Biology; In vivo; Gene; Immunization; Biotechnology; Gene expression; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001626802,0.0004697646,0.0002584422,0.0002143027,0.00006681839,0.0002384885,0.0001900408,0.0003801622,0.0006813997],"category_scores_gemma":[0.0001248062,0.0001144482,0.0002156926,0.000116438,0.000189801,0.0002264111,0.0002622681,0.0003066533,0.0002824253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001845078,"about_ca_system_score_gemma":0.0002573159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002093762,"about_ca_topic_score_gemma":0.00034853,"domain_scores_codex":[0.9998847,0.00002039662,0.000008209031,0.00003291724,0.00003442818,0.00001926628],"domain_scores_gemma":[0.9999403,0.00001176615,0.00001592006,0.000005822037,0.000009784391,0.00001641195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008528647,0.00004080686,0.0001178252,0.00006103094,0.000008706837,0.00005206739,0.0000062014,0.0002122271,0.9947293,0.0000747349,0.00004144201,0.004570433],"study_design_scores_gemma":[0.00003135746,0.001114591,0.0006283442,0.000007333389,0.00003703091,0.0002194991,0.000005957639,0.001605259,0.99404,0.00003772942,0.002267404,0.000005458805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9663951,0.003960249,0.02666666,0.0001668635,0.00009064839,0.0001691795,0.0000975739,0.0002037946,0.002249876],"genre_scores_gemma":[0.9809956,0.001377445,0.01453158,0.00009287028,0.00003021625,0.0001049193,0.0001698265,0.00003725882,0.002660361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006813997,"threshold_uncertainty_score":0.00227952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01273255562458519,"score_gpt":0.2397753319293494,"score_spread":0.2270427763047642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}