{"id":"W2085701236","doi":"10.1016/j.febslet.2009.08.031","title":"SIRT1 markedly extends replicative lifespan if the NAD<sup>+</sup> salvage pathway is enhanced","year":2009,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"Canadian Institutes of Health Research; Krembil Foundation; Heart and Stroke Foundation of Canada","keywords":"Nicotinamide phosphoribosyltransferase; NAD+ kinase; Sirtuin 1; Sirtuin; Senescence; Longevity; Nicotinamide adenine dinucleotide; Nucleotide salvage; Biology; Cell biology; Nicotinamide mononucleotide; Gene silencing; Gene; SIRT6; Chemistry; Biochemistry; Molecular biology; Enzyme; Genetics; Downregulation and upregulation; Nucleotide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000540343,0.0003720272,0.0005290614,0.000144334,0.0002494031,0.0000429306,0.0003548638,0.0001549592,0.0004802051],"category_scores_gemma":[0.000259268,0.0002242947,0.0002586193,0.0004355512,0.0002672955,0.00009208678,0.00005039985,0.0007164596,0.0001663752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001185517,"about_ca_system_score_gemma":0.00008192668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000311081,"about_ca_topic_score_gemma":0.000001507027,"domain_scores_codex":[0.9974368,0.0001405521,0.0004765414,0.000656151,0.0006645744,0.0006254204],"domain_scores_gemma":[0.997956,0.0002081841,0.00016832,0.001277328,0.0001066845,0.0002834162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001005457,0.0003648745,0.0009046532,0.00007922696,0.0004021626,0.0005875115,0.009356426,0.0000886632,0.4489037,0.0003330961,0.4276607,0.1103135],"study_design_scores_gemma":[0.01317174,0.005055484,0.1532398,0.001345898,0.0009015423,0.0007002276,0.005321391,0.003873341,0.1425694,0.0004339501,0.6715822,0.001805019],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7576017,0.0008193934,0.001045087,0.227795,0.0002859668,0.0007815225,0.00001735248,0.0001875833,0.01146637],"genre_scores_gemma":[0.8286238,0.0001619719,0.0004550335,0.1640617,0.001921155,0.0000457428,0.00003558686,0.00004165838,0.004653293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3063342,"threshold_uncertainty_score":0.9146471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009755339176709952,"score_gpt":0.2569934533207506,"score_spread":0.2472381141440406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}