{"id":"W2085701236","doi":"10.1016/j.febslet.2009.08.031","title":"SIRT1 markedly extends replicative lifespan if the NAD<sup>+</sup> salvage pathway is enhanced","year":2009,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"Canadian Institutes of Health Research; Krembil Foundation; Heart and Stroke Foundation of Canada","keywords":"Nicotinamide phosphoribosyltransferase; NAD+ kinase; Sirtuin 1; Sirtuin; Senescence; Longevity; Nicotinamide adenine dinucleotide; Nucleotide salvage; Biology; Cell biology; Nicotinamide mononucleotide; Gene silencing; Gene; SIRT6; Chemistry; Biochemistry; Molecular biology; Enzyme; Genetics; Downregulation and upregulation; Nucleotide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001854999,0.0002424456,0.0001998867,0.0001389104,0.00009170923,0.000212648,0.0001414888,0.0002135784,0.001381325],"category_scores_gemma":[0.0001055953,0.0001081021,0.0002089518,0.00009132533,0.000199872,0.0001615212,0.0001510513,0.0004138127,0.0004121401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001591526,"about_ca_system_score_gemma":0.0001173865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000343448,"about_ca_topic_score_gemma":0.000606024,"domain_scores_codex":[0.9999257,0.00001913644,0.00000793204,0.00001363868,0.00001597864,0.00001750968],"domain_scores_gemma":[0.9998957,0.00002016272,0.00002074614,0.00002333497,0.00001153354,0.00002852954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001253282,0.00001251636,0.0001542554,0.00001851104,0.000003743628,0.00002996972,0.00001089405,0.00002599981,0.9983234,0.00007115648,0.00003190474,0.001192368],"study_design_scores_gemma":[0.00001005106,0.0003463541,0.003701979,0.000003261199,0.00001225437,0.0001592547,0.00001827223,0.0003499774,0.9926473,0.00005513986,0.002693433,0.000002698529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993099,0.002122199,0.001896755,0.0002228584,0.00004707442,0.000007401613,0.0002326253,0.00014766,0.002224386],"genre_scores_gemma":[0.9954975,0.0006228724,0.001106542,0.00005609202,0.00001536854,0.000007491007,0.0003308077,0.0000147071,0.002348687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001381325,"threshold_uncertainty_score":0.004621029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009755339176709952,"score_gpt":0.2569934533207506,"score_spread":0.2472381141440406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}