{"id":"W2085710584","doi":"10.1172/jci34470","title":"A skewed view of X chromosome inactivation","year":2007,"lang":"en","type":"letter","venue":"Journal of Clinical Investigation","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"University of California, San Francisco; National Institutes of Health","keywords":"X-inactivation; X chromosome; Skewed X-inactivation; Genetics; Biology; Somatic cell; XIST; Chromosome; Locus (genetics); Dosage compensation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001672429,0.000229608,0.0007686452,0.0001290303,0.00003507547,0.00002168584,0.0003527542,0.001253705,0.00007388867],"category_scores_gemma":[0.001651128,0.0001910217,0.0005712969,0.0001300048,0.0004197902,0.0000149805,0.00006280519,0.001121225,0.000007835349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001605766,"about_ca_system_score_gemma":0.0004147814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004434481,"about_ca_topic_score_gemma":0.000002138938,"domain_scores_codex":[0.9958786,0.0003284372,0.002782671,0.0002502301,0.0005663966,0.0001936527],"domain_scores_gemma":[0.9952025,0.0003107029,0.003135209,0.0002820356,0.0009343276,0.0001352462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000329184,0.00027852,0.003888676,0.0006848375,0.0005392153,0.0001090187,0.00008052558,0.00001572429,0.02042813,0.00009717658,0.940547,0.03300191],"study_design_scores_gemma":[0.00136443,0.002868422,0.007432523,0.0004961683,0.0001930328,0.0001079712,0.00006022414,0.00001345525,0.05556309,0.002399109,0.9291514,0.000350149],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.858636,0.001254735,0.0008704,0.1348922,0.002128107,0.0003037268,0.00003082175,0.00000992703,0.001874031],"genre_scores_gemma":[0.4357161,0.002753206,0.004435922,0.5290661,0.02324863,0.000006766285,0.0005446769,0.0000874238,0.004141198],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.4229199,"threshold_uncertainty_score":0.9669718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05276258147147096,"score_gpt":0.3493210499933569,"score_spread":0.2965584685218859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}