{"id":"W2085710584","doi":"10.1172/jci34470","title":"A skewed view of X chromosome inactivation","year":2007,"lang":"en","type":"letter","venue":"Journal of Clinical Investigation","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"University of California, San Francisco; National Institutes of Health","keywords":"X-inactivation; X chromosome; Skewed X-inactivation; Genetics; Biology; Somatic cell; XIST; Chromosome; Locus (genetics); Dosage compensation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007770487,0.0006448181,0.0006383008,0.0004486023,0.0007180294,0.001289252,0.0009891306,0.009293394,0.005138875],"category_scores_gemma":[0.004829937,0.0002374609,0.0004170602,0.0002722854,0.002420862,0.001892651,0.0006092823,0.009953748,0.003890483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000869374,"about_ca_system_score_gemma":0.0003337029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003822141,"about_ca_topic_score_gemma":0.0004117113,"domain_scores_codex":[0.9991074,0.0003127155,0.00007109706,0.0001913397,0.0002265847,0.00009082888],"domain_scores_gemma":[0.9982405,0.0009804325,0.0001450284,0.0001742435,0.0002930423,0.0001667426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004895565,0.000120196,0.007482026,0.0003562683,0.00008612514,0.07182945,0.0005581293,0.0004907799,0.006087794,0.04882368,0.7753427,0.08833318],"study_design_scores_gemma":[0.0003152824,0.0003454886,0.004319664,0.0003525759,0.00006358263,0.2436646,0.0006033772,0.002096155,0.002883095,0.06037327,0.6848891,0.00009378086],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0140636,0.01462247,0.003661096,0.9085957,0.0295719,0.00003642107,0.0001196257,0.0002866209,0.02904266],"genre_scores_gemma":[0.163445,0.01998075,0.00265185,0.6334652,0.1480255,0.00007283918,0.0001058365,0.00007824383,0.03217488],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.009293394,"threshold_uncertainty_score":0.01719123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05276258147147096,"score_gpt":0.3493210499933569,"score_spread":0.2965584685218859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}