{"id":"W2085762585","doi":"10.1016/j.tetasy.2006.02.007","title":"Studies on Cu-catalyzed asymmetric alkynylation of tetrahydroisoquinoline derivatives","year":2006,"lang":"en","type":"article","venue":"Tetrahedron Asymmetry","topic":"Synthesis and Biological Activity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":158,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Tetrahydroisoquinoline; Alkynylation; Enantioselective synthesis; Electrophile; Catalysis; Chemistry; Ligand (biochemistry); Combinatorial chemistry; Stereochemistry; Medicinal chemistry; Organic chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003332203,0.0002555453,0.0003735167,0.0002060822,0.00007600486,0.000011395,0.0002098078,0.0002146835,0.00001306422],"category_scores_gemma":[0.0006834155,0.0001943695,0.0001812846,0.0004971056,0.0001683045,0.000007590987,0.0000923066,0.0001163969,0.00001716064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003048681,"about_ca_system_score_gemma":0.00002366574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003701657,"about_ca_topic_score_gemma":0.00002035908,"domain_scores_codex":[0.9984653,0.0001136641,0.0004380871,0.0004714926,0.0002360949,0.0002753802],"domain_scores_gemma":[0.9990581,0.0001437993,0.0002682028,0.0003646513,0.0001148544,0.0000504394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001728327,0.0006577614,0.03539006,0.00004464932,0.0001496356,0.000002474701,0.00001194582,0.00008798821,0.9430056,0.0009798791,0.001149299,0.01834787],"study_design_scores_gemma":[0.0004311518,0.0005031636,0.1237372,0.00002405614,0.00002388203,0.000003962171,0.0001136113,0.00004678988,0.873305,0.0004148464,0.001154394,0.0002420134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917307,0.002032296,0.00043139,0.0001369676,0.0001759447,0.0001807999,0.000033742,0.00003350225,0.005244672],"genre_scores_gemma":[0.9981529,0.0001590101,0.0008718693,0.00009019076,0.0003092786,0.00001401454,0.000115315,0.00002093744,0.0002665454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08834711,"threshold_uncertainty_score":0.7926156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0226271531121644,"score_gpt":0.2855132496485611,"score_spread":0.2628860965363967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}