{"id":"W2085764065","doi":"10.1021/jo050326w","title":"Synthetic Studies in the Intramolecular Carbocyclization of <i>N</i>-Acyloxyiminium Ions. Stereoelectronic and Steric Implications of Nucleophilic Alkene, Alkyne, and Allene Tethers","year":2005,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Allene; Nucleophile; Carbocation; Alkyne; Alkene; Bicyclic molecule; Steric effects; Intramolecular force; Stereochemistry; Aryl; Alkane stereochemistry; Medicinal chemistry; Cyclopropane; Enyne; Enantiopure drug; Alkyl; Ring (chemistry); Organic chemistry; Molecule; Enantioselective synthesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003272094,0.0003881469,0.0001345344,0.0001115675,0.0001880863,0.0002740371,0.0003197942,0.000221883,0.001125533],"category_scores_gemma":[0.0002852198,0.0001250865,0.0002306369,0.0001178414,0.000266323,0.0003105181,0.0002042045,0.0004346266,0.0003719086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002810608,"about_ca_system_score_gemma":0.0002402882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004267237,"about_ca_topic_score_gemma":0.0005934915,"domain_scores_codex":[0.9998538,0.00002952232,0.00001233652,0.00002918906,0.00002756973,0.00004752891],"domain_scores_gemma":[0.9998724,0.00002495248,0.00004008044,0.000019096,0.00001674409,0.00002672307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001466435,0.00007036366,0.0001541797,0.00008765238,0.000006693225,0.0002341906,0.0000943803,0.0004044753,0.9936884,0.001104153,0.00006131108,0.003947484],"study_design_scores_gemma":[0.00003312943,0.000644604,0.0003897848,0.0000060548,0.00001209599,0.0002971404,0.00002786079,0.0003335915,0.9956406,0.00007681007,0.002531519,0.000006689907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841389,0.001361342,0.005239682,0.00009250313,0.00003514889,0.0001056491,0.00008957386,0.0000434119,0.008893701],"genre_scores_gemma":[0.9920667,0.0009734472,0.004974763,0.00003711125,0.00001343536,0.00003812121,0.0001397648,0.00001722443,0.00173933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001125533,"threshold_uncertainty_score":0.003765345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01548185837995964,"score_gpt":0.2530565494720868,"score_spread":0.2375746910921272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}