{"id":"W2085785641","doi":"10.1016/j.biopsych.2010.05.004","title":"T-Type Calcium Channel Antagonism Decreases Motivation for Nicotine and Blocks Nicotine- and Cue-Induced Reinstatement for a Response Previously Reinforced with Nicotine","year":2010,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health","funders":"Merck","keywords":"Nicotine; Pharmacology; Antagonist; Calcium channel; Self-administration; Antagonism; Psychology; Chemistry; Medicine; Internal medicine; Calcium; Neuroscience; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007635932,0.0004319871,0.0004311509,0.00006776896,0.0002630202,0.00004483721,0.0002229487,0.0004571128,0.00001062997],"category_scores_gemma":[0.001095668,0.0003096205,0.0001168836,0.000128789,0.0001843928,0.00001217577,0.0001793968,0.0002364186,0.000001140146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001496018,"about_ca_system_score_gemma":0.0001915122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001930621,"about_ca_topic_score_gemma":0.00004101122,"domain_scores_codex":[0.9977492,0.0001053949,0.0005397458,0.0009042656,0.0001307,0.0005706729],"domain_scores_gemma":[0.9985144,0.0001992121,0.0003056666,0.000458536,0.0002553971,0.0002668485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009419628,0.0002417373,0.01381819,0.00007050321,0.0001367452,1.067887e-7,0.00004471565,0.000007986974,0.9738114,0.0002825876,0.001423651,0.000742736],"study_design_scores_gemma":[0.01528203,0.02337212,0.01424498,0.0001260532,0.0002384981,0.0001297749,0.0004521421,0.0006987246,0.9187682,0.0003650371,0.02481818,0.001504254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924847,0.0005167623,0.002519244,0.001412482,0.0006809525,0.002215174,0.00007403751,0.00006110693,0.00003557379],"genre_scores_gemma":[0.9882992,0.0002103399,0.00894078,0.0006044998,0.0007653984,0.0002677261,0.0004438955,0.00005226417,0.000415929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05504321,"threshold_uncertainty_score":0.9999356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02845634896753838,"score_gpt":0.2991305447492827,"score_spread":0.2706741957817443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}