{"id":"W2085818415","doi":"10.1101/gad.946501","title":"Chromatin-specific regulation of LEF-1–β-catenin transcription activation and inhibition in vitro","year":2001,"lang":"en","type":"article","venue":"Genes & Development","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of California, San Diego; National Institutes of Health; Canadian Institute for Theoretical Astrophysics","keywords":"Transactivation; Biology; Chromatin; Wnt signaling pathway; Enhancer; Molecular biology; Chromatin remodeling; Cell biology; Transcription factor; Transcription (linguistics); Coactivator; Signal transduction; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003367189,0.0007655151,0.0004304328,0.0002587943,0.0002453964,0.0004545032,0.0003768095,0.0002317259,0.002814611],"category_scores_gemma":[0.0002386416,0.0003573382,0.0005037796,0.0001854909,0.0004188069,0.0001685129,0.000501999,0.001057743,0.00103486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007795785,"about_ca_system_score_gemma":0.0003190989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001537751,"about_ca_topic_score_gemma":0.003631992,"domain_scores_codex":[0.9995634,0.00009868671,0.0000372475,0.0001075572,0.0001115909,0.0000813537],"domain_scores_gemma":[0.9997889,0.00007900567,0.00003688281,0.00004729022,0.00001810937,0.00002978702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004570053,0.0000316434,0.00006420545,0.00003146975,0.000005738051,0.00001282375,0.00001416059,0.00004841372,0.9987953,0.00008409719,0.00004094999,0.0008255044],"study_design_scores_gemma":[0.00001204351,0.000100024,0.0007484651,0.000003887895,0.000006424376,0.00004250574,0.000004335185,0.000404605,0.9965318,0.00002558866,0.002116987,0.000003499041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9585241,0.01022622,0.01994264,0.0003022356,0.0002029203,0.0002028982,0.001520289,0.0005213633,0.008557252],"genre_scores_gemma":[0.9746141,0.002087574,0.009513188,0.0001358048,0.0000541462,0.000220454,0.003911895,0.00009683399,0.009366024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002814611,"threshold_uncertainty_score":0.009415865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01428570098142479,"score_gpt":0.2173691155585387,"score_spread":0.2030834145771139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}