{"id":"W2085831929","doi":"10.4061/2011/284728","title":"Genetics and Genomics of Late‐Onset Alzheimer′s Disease and Its Endophenotypes","year":2011,"lang":"en","type":"article","venue":"International Journal of Alzheimer s Disease","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute on Aging; Medical Research Council; Wellcome Trust","keywords":"Endophenotype; Genomics; Genetics; Disease; Biology; Psychology; Medicine; Neuroscience; Genome; Cognition; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001045444,0.0001422995,0.0001401812,0.0001093253,0.0000339902,0.00002515407,0.0002548084,0.00004785884,0.00008150178],"category_scores_gemma":[0.0001180188,0.0001355056,0.0001114311,0.0000278872,0.0001075516,0.00002379561,0.0001645659,0.00009589983,0.000003962707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007694582,"about_ca_system_score_gemma":0.0001734426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008740701,"about_ca_topic_score_gemma":0.000002484746,"domain_scores_codex":[0.9990519,0.00004903543,0.0003806242,0.0001792004,0.0002192633,0.0001199388],"domain_scores_gemma":[0.998679,0.00001744083,0.0003269141,0.0001523668,0.0004755173,0.000348802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02293461,0.003874875,0.3978528,0.0001366779,0.03093447,0.001523802,0.002519554,0.0008048907,0.4804764,0.003436355,0.005911562,0.04959405],"study_design_scores_gemma":[0.002954549,0.0007343793,0.5815582,0.0001838978,0.003678784,0.0003290539,0.0001444993,0.0006407044,0.395231,0.004081775,0.009730457,0.0007326968],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9568479,0.04193588,0.000111765,0.0002429448,0.0003999968,0.0001263427,0.0001896979,0.000003262625,0.0001422259],"genre_scores_gemma":[0.9964529,0.002058215,0.000973749,0.0001905124,0.0002476375,0.000005791759,0.00002481721,0.00002136192,0.00002506011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1837055,"threshold_uncertainty_score":0.5525758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02953592130347041,"score_gpt":0.2820458911675527,"score_spread":0.2525099698640823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}