{"id":"W2085899816","doi":"10.1016/j.crohns.2012.01.011","title":"Treatment of Crohn's disease patients with infliximab is detrimental for the survival of Mycobacterium avium ssp. paratuberculosis within macrophages and shows a remarkable decrease in the immunogenicity of mycobacterial proteins","year":2012,"lang":"en","type":"letter","venue":"Journal of Crohn s and Colitis","topic":"Mycobacterium research and diagnosis","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Paratuberculosis; Mycobacterium; Microbiology; Monoclonal antibody; Immune system; Mycobacterium avium subspecies paratuberculosis; Crohn's disease; Immunogenicity; Biology; Macrophage; Cytokine; Tumor necrosis factor alpha; Antibody; Immunology; Mycobacterium smegmatis; Disease; Virology; Medicine; Mycobacterium tuberculosis; Tuberculosis; Bacteria; In vitro; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005572121,0.0004163423,0.001267961,0.0002329319,0.0001036904,0.00007951719,0.0002436323,0.0002490377,0.0001375053],"category_scores_gemma":[0.0002669385,0.0002159521,0.0003727377,0.0001991498,0.0004310909,0.000220761,0.00007688234,0.0004359845,2.247788e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001319245,"about_ca_system_score_gemma":0.0006447314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00105248,"about_ca_topic_score_gemma":0.00006825801,"domain_scores_codex":[0.9968861,0.0003266466,0.001114298,0.0002663909,0.0009129184,0.0004936378],"domain_scores_gemma":[0.996515,0.00075821,0.001265931,0.0004619619,0.0006883371,0.000310562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2503186,0.006722834,0.6987839,0.005871405,0.004423146,0.001616685,0.004496106,8.981002e-7,0.002208084,0.00004061193,0.02164811,0.003869566],"study_design_scores_gemma":[0.009457054,0.004875407,0.9717159,0.00079094,0.001805152,0.0001050812,0.0001944616,0.000003761905,0.004468364,0.0000294576,0.006343774,0.000210669],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832476,0.003581833,0.000004655219,0.007920084,0.0002067647,0.002467849,0.002542301,0.000002250605,0.00002663108],"genre_scores_gemma":[0.9938114,0.002072031,0.0002177524,0.00265343,0.0008001611,0.0002075495,0.0001216983,0.00004419198,0.000071793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.272932,"threshold_uncertainty_score":0.8806271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01702734524274297,"score_gpt":0.2677574147032442,"score_spread":0.2507300694605012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}