{"id":"W2085899816","doi":"10.1016/j.crohns.2012.01.011","title":"Treatment of Crohn's disease patients with infliximab is detrimental for the survival of Mycobacterium avium ssp. paratuberculosis within macrophages and shows a remarkable decrease in the immunogenicity of mycobacterial proteins","year":2012,"lang":"en","type":"letter","venue":"Journal of Crohn s and Colitis","topic":"Mycobacterium research and diagnosis","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Paratuberculosis; Mycobacterium; Microbiology; Monoclonal antibody; Immune system; Mycobacterium avium subspecies paratuberculosis; Crohn's disease; Immunogenicity; Biology; Macrophage; Cytokine; Tumor necrosis factor alpha; Antibody; Immunology; Mycobacterium smegmatis; Disease; Virology; Medicine; Mycobacterium tuberculosis; Tuberculosis; Bacteria; In vitro; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004216708,0.0004217098,0.000935688,0.0002891622,0.0008641355,0.000625671,0.0003445913,0.004174056,0.002936443],"category_scores_gemma":[0.003403001,0.0001938727,0.0003868341,0.0003222315,0.0005615772,0.0005733286,0.0001386094,0.002660557,0.002389368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006109154,"about_ca_system_score_gemma":0.0001961636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003787148,"about_ca_topic_score_gemma":0.0008017344,"domain_scores_codex":[0.999402,0.0002291743,0.00006369297,0.00006411073,0.0001326416,0.0001082887],"domain_scores_gemma":[0.9986071,0.0007012485,0.0001681376,0.00009050997,0.0002197272,0.0002132888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004584312,0.0009916563,0.08107661,0.001155266,0.0001552755,0.4673935,0.0008865158,0.0003856272,0.03200532,0.002490961,0.23216,0.176715],"study_design_scores_gemma":[0.0008907079,0.003066416,0.1451691,0.0007033508,0.0001660893,0.5547042,0.000719203,0.001893163,0.004799408,0.002497937,0.285313,0.00007746553],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.4365811,0.03490278,0.002486821,0.409864,0.01979206,0.0002505427,0.0002376843,0.0004253438,0.09545958],"genre_scores_gemma":[0.7800169,0.01389243,0.001586623,0.1357154,0.0458499,0.0001248307,0.0001825494,0.00008025468,0.02255112],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.004174056,"threshold_uncertainty_score":0.009823442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01702734524274297,"score_gpt":0.2677574147032442,"score_spread":0.2507300694605012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}