{"id":"W2085950149","doi":"10.1074/jbc.m110.159046","title":"ERK1/2 Phosphorylate Raptor to Promote Ras-dependent Activation of mTOR Complex 1 (mTORC1)","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":267,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Cancer Society Research Institute; Terry Fox Foundation; National Institutes of Health; American Diabetes Association","keywords":"mTORC1; Phosphorylation; MAPK/ERK pathway; PI3K/AKT/mTOR pathway; Cell biology; Biology; Signal transduction; Kinase; P70-S6 Kinase 1","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007734757,0.0003610243,0.0001375423,0.0002045828,0.0001660017,0.0001698547,0.0001197667,0.0001400484,0.001709973],"category_scores_gemma":[0.00006994056,0.0001233004,0.0001865843,0.000120299,0.0001166447,0.0001403734,0.000186714,0.0003367163,0.0008956779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001836658,"about_ca_system_score_gemma":0.0001055143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002103872,"about_ca_topic_score_gemma":0.0004500633,"domain_scores_codex":[0.9999472,0.000007728896,0.00000343127,0.00001112,0.00001518682,0.00001540763],"domain_scores_gemma":[0.9999679,0.000004154308,0.0000127504,0.000002837721,0.000005371051,0.000006914677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001385222,0.00002804497,0.0002555596,0.00008475773,0.000009386268,0.0001213615,0.00001567862,0.0001351359,0.995708,0.000250734,0.0001978248,0.003054986],"study_design_scores_gemma":[0.00001847571,0.00007327133,0.007528744,0.000006646697,0.00001081991,0.0007837739,0.00001708323,0.001282079,0.9847727,0.0001593368,0.005342267,0.00000487543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870416,0.003072721,0.004365125,0.0002154647,0.00004632881,0.00002810863,0.0006022659,0.0001317349,0.004496528],"genre_scores_gemma":[0.9876776,0.002107275,0.00542189,0.000107887,0.00002781972,0.00002858712,0.001065479,0.0000242122,0.003539236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001709973,"threshold_uncertainty_score":0.005720437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02374616446765752,"score_gpt":0.2800878798209242,"score_spread":0.2563417153532667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}