{"id":"W2085961304","doi":"10.1371/journal.pone.0103573","title":"SIRT2 Deficiency Modulates Macrophage Polarization and Susceptibility to Experimental Colitis","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Associazione Italiana per la Ricerca sul Cancro; École Polytechnique Fédérale de Lausanne; Heart and Stroke Foundation of Canada; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Meso Scale Diagnostics; National Institutes of Health; National Science Foundation","keywords":"SIRT2; Sirtuin; Colitis; Biology; Macrophage polarization; Inflammation; Histone; Chemokine; Cancer research; Immunology; Phenotype; Genetics; Acetylation; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001988093,0.0001144008,0.0002632699,0.00007235944,0.00009020673,0.00001749211,0.00004625685,0.00006919189,0.0002196972],"category_scores_gemma":[0.0002455117,0.00009306353,0.00002490974,0.0001334804,0.00008131823,0.00004381486,0.00004667427,0.0001073949,0.00003253703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004785508,"about_ca_system_score_gemma":0.00001655443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007421539,"about_ca_topic_score_gemma":0.000007024717,"domain_scores_codex":[0.9989636,0.00003968005,0.0001855945,0.0002787941,0.0003205467,0.0002117853],"domain_scores_gemma":[0.9993605,0.00003804858,0.00002971674,0.000248952,0.00008261848,0.0002401712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001338385,0.001263195,0.09237601,0.0001268285,0.00003470691,0.000007731135,0.0004359784,0.000002369975,0.9041381,0.0002717304,0.00006445654,0.00114499],"study_design_scores_gemma":[0.002746934,0.003084214,0.5450829,0.0003418885,0.0001969027,0.00002443944,0.0004376006,0.005420807,0.4421386,0.000107741,0.0001688848,0.0002490664],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966193,0.0005038293,0.0001888198,0.0008080618,0.00004811041,0.0004502046,0.000005218926,0.00006159581,0.001314809],"genre_scores_gemma":[0.9952512,0.00001670726,0.002660403,0.0009560992,0.0002277595,0.00001542935,0.00001701524,0.00001789006,0.0008374348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4619995,"threshold_uncertainty_score":0.3795021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02253530488069861,"score_gpt":0.2515026543986547,"score_spread":0.2289673495179561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}