{"id":"W2085961304","doi":"10.1371/journal.pone.0103573","title":"SIRT2 Deficiency Modulates Macrophage Polarization and Susceptibility to Experimental Colitis","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Associazione Italiana per la Ricerca sul Cancro; École Polytechnique Fédérale de Lausanne; Heart and Stroke Foundation of Canada; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Meso Scale Diagnostics; National Institutes of Health; National Science Foundation","keywords":"SIRT2; Sirtuin; Colitis; Biology; Macrophage polarization; Inflammation; Histone; Chemokine; Cancer research; Immunology; Phenotype; Genetics; Acetylation; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001386068,0.0003349491,0.0003592181,0.0002571925,0.0001033388,0.0002355563,0.0001668084,0.0003551134,0.002120271],"category_scores_gemma":[0.0001302859,0.0001232674,0.0002573063,0.0001865103,0.000250006,0.0001542215,0.0001794508,0.0005647517,0.0003683336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001543172,"about_ca_system_score_gemma":0.0001245174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001445978,"about_ca_topic_score_gemma":0.000295021,"domain_scores_codex":[0.9998764,0.00002251468,0.00001217191,0.0000251669,0.00002472206,0.0000391116],"domain_scores_gemma":[0.999856,0.000008534584,0.00004947781,0.00001124745,0.00001354872,0.00006113401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001660713,0.0001716313,0.002064909,0.00008627298,0.00002276725,0.00009800858,0.00002216267,0.00004716548,0.9936033,0.00006277228,0.0001062931,0.00205402],"study_design_scores_gemma":[0.0004204188,0.004790058,0.09319897,0.00005000905,0.0002597313,0.001063928,0.0001886273,0.001608058,0.8903193,0.0002550258,0.0078174,0.00002843824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963064,0.001639937,0.0007691809,0.00009614894,0.00005205782,0.00002129943,0.0003105236,0.00007285213,0.000731607],"genre_scores_gemma":[0.995927,0.0009871606,0.0006498955,0.00008998908,0.00002889451,0.000045909,0.0004906548,0.00001892237,0.001761463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002120271,"threshold_uncertainty_score":0.007092953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02253530488069861,"score_gpt":0.2515026543986547,"score_spread":0.2289673495179561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}