{"id":"W2085971293","doi":"10.1002/cbic.201402512","title":"Identification and Characterization of a Small‐Molecule Inhibitor of Death‐Associated Protein Kinase 1","year":2014,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministero dello Sviluppo Economico; Strategic Research Council; Novo Nordisk; Ontario Ministry of Economic Development and Innovation; Genome Canada; Wellcome Trust; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Identification (biology); Small molecule; Chemistry; Kinase; Protein kinase A; Computational biology; Molecule; Biochemistry; Cell biology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001604816,0.0000902251,0.0001296126,0.00002823177,0.00002158749,0.000006865484,0.00007629598,0.0001276886,0.000003453085],"category_scores_gemma":[0.0001548954,0.00009390157,0.00004036227,0.00005983458,0.00004584928,0.000002676462,0.00005173614,0.00002997739,0.000001165158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005048929,"about_ca_system_score_gemma":0.00002411634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005037643,"about_ca_topic_score_gemma":0.000002065362,"domain_scores_codex":[0.9993771,0.00003260084,0.000223998,0.0001989927,0.00006949654,0.00009780344],"domain_scores_gemma":[0.9994131,0.000003796585,0.0002114787,0.0002112454,0.0001192438,0.00004114539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002476763,0.00007369935,0.0007947507,0.00008227438,0.00001568093,1.541155e-7,0.00003646257,6.991594e-8,0.9981671,0.0002053941,0.00001472219,0.0005849247],"study_design_scores_gemma":[0.0003736065,0.0001502517,0.007258958,0.00003625914,0.0000135563,0.000001038355,0.000008955947,0.00004999408,0.9917573,0.00003615749,0.0002219536,0.00009193808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981074,0.00005376079,0.001265245,0.0000249501,0.00003364409,0.000185587,0.00002212068,0.00000724045,0.000300059],"genre_scores_gemma":[0.9990051,0.00001026318,0.0001069176,0.00001823217,0.00005730413,0.0000233515,0.0003521388,0.00001271133,0.0004139442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006464208,"threshold_uncertainty_score":0.3829195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00832888224529081,"score_gpt":0.2011807604510626,"score_spread":0.1928518782057718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}