{"id":"W2086020450","doi":"10.1007/s10637-011-9697-2","title":"Phase I study of axitinib (AG-013736) in combination with gemcitabine in patients with advanced pancreatic cancer","year":2011,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Pfizer","keywords":"Gemcitabine; Axitinib; Medicine; Pharmacokinetics; Pancreatic cancer; Adverse effect; Internal medicine; Oncology; Pharmacology; Cancer; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001553472,0.001956235,0.00418059,0.0009296834,0.00053438,0.001464709,0.001152749,0.001240036,0.003841795],"category_scores_gemma":[0.0009603176,0.001121758,0.002309196,0.001093665,0.001492359,0.001373349,0.0005687136,0.004905527,0.001004531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001664494,"about_ca_system_score_gemma":0.002475552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002635962,"about_ca_topic_score_gemma":0.007683186,"domain_scores_codex":[0.9994431,0.0002613171,0.00002648174,0.00009653401,0.00003658836,0.000136047],"domain_scores_gemma":[0.9994296,0.00009522001,0.00008078235,0.00005376868,0.00002482553,0.000315772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7664427,0.07160089,0.005972586,0.001291998,0.002469563,0.0003740455,0.0004133825,0.005639659,0.02803502,0.0005267537,0.005905531,0.1113279],"study_design_scores_gemma":[0.5793227,0.4032018,0.008074897,0.0000503389,0.0009077275,0.0002919343,0.000103292,0.001709295,0.003111507,0.0002406994,0.002942138,0.00004353225],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893846,0.00406883,0.0004146305,0.0006850772,0.0002644855,0.00147524,0.001178539,0.0001435593,0.002385028],"genre_scores_gemma":[0.985838,0.004937307,0.001529267,0.000670605,0.0002618891,0.001548069,0.002369706,0.00006011725,0.002784959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00418059,"threshold_uncertainty_score":0.01285207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03711149899049349,"score_gpt":0.3264996208753025,"score_spread":0.289388121884809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}