{"id":"W2086031323","doi":"10.1038/nsmb.1857","title":"Replication stress checkpoint signaling controls tRNA gene transcription","year":2010,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Biology; Cell biology; Transcription (linguistics); RNA polymerase III; Genetics; Gene; DNA replication factor CDT1; G2-M DNA damage checkpoint; Origin recognition complex; DNA replication; Control of chromosome duplication; Eukaryotic DNA replication; Cell cycle checkpoint; RNA; Cell cycle; RNA polymerase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001473165,0.0004853561,0.0002658805,0.0002750084,0.0005442231,0.001125344,0.0003494361,0.0005100228,0.004832189],"category_scores_gemma":[0.0003032323,0.0003222033,0.0003093109,0.0001698624,0.0003458546,0.000746211,0.0005719766,0.0008205242,0.001823249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008113698,"about_ca_system_score_gemma":0.0003520862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006946232,"about_ca_topic_score_gemma":0.001443643,"domain_scores_codex":[0.9998413,0.00001165446,0.000007769409,0.00006199481,0.00002506332,0.00005225408],"domain_scores_gemma":[0.9997501,0.00005314657,0.00004882578,0.00003877303,0.00003347242,0.00007560072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002420361,0.00001063685,0.000258456,0.00001809417,0.000002636516,0.00005017117,0.00001802277,0.00009059042,0.9958346,0.0006982453,0.0002257114,0.002550783],"study_design_scores_gemma":[0.00001976438,0.0001030311,0.006720156,0.000008948083,0.000004735406,0.0001189476,0.00007534282,0.002016908,0.9858342,0.0007191742,0.004367248,0.00001171145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770736,0.003818984,0.00820524,0.0009037547,0.0004402449,0.00002601587,0.00111109,0.001173181,0.007247811],"genre_scores_gemma":[0.9920036,0.0006414492,0.001286056,0.0001104688,0.00003866335,0.00001220187,0.0007502642,0.0001548537,0.005002363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004832189,"threshold_uncertainty_score":0.01616526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004619150004850137,"score_gpt":0.2880781032049148,"score_spread":0.2834589532000647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}