{"id":"W2086031901","doi":"10.1074/jbc.m007629200","title":"Association with the Nuclear Matrix and Interaction with Groucho and RUNX Proteins Regulate the Transcription Repression Activity of the Basic Helix Loop Helix Factor Hes1","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Psychological repression; Basic helix-loop-helix; Transcription factor; HES1; Transcription (linguistics); Helix (gastropod); Association (psychology); Genetics; Cell biology; Biology; DNA-binding protein; Psychology; Gene; Notch signaling pathway; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001478386,0.0004368043,0.0002601802,0.0001473009,0.0001867226,0.000412602,0.0001790551,0.0001641812,0.0009211965],"category_scores_gemma":[0.0002106014,0.0002376113,0.0002168519,0.00008383312,0.0003006049,0.0002525994,0.0004976974,0.0003378607,0.0003833755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002608285,"about_ca_system_score_gemma":0.0002054225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005319123,"about_ca_topic_score_gemma":0.0008780027,"domain_scores_codex":[0.9998215,0.00002655465,0.000008057203,0.00004154105,0.00004871239,0.00005362939],"domain_scores_gemma":[0.9999167,0.00001100667,0.00002767933,0.000006857905,0.000009716301,0.00002801094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009657656,0.00001178078,0.0006955269,0.00003207272,0.000005173362,0.0000560772,0.00002192281,0.00007788406,0.9975805,0.0002646148,0.00004311985,0.001114595],"study_design_scores_gemma":[0.00004545812,0.0001861179,0.06937686,0.00002106344,0.00003248275,0.0004667568,0.0001571345,0.005889039,0.9179713,0.0003543398,0.005482013,0.00001756316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931636,0.002529083,0.002385713,0.00009821171,0.00001858107,0.00001055187,0.00009655353,0.00007706747,0.001620618],"genre_scores_gemma":[0.9955842,0.0009332506,0.0008508679,0.00003147652,0.000009957221,0.00001615203,0.0002495181,0.00002187187,0.002302689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009211965,"threshold_uncertainty_score":0.003081679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01471089863935575,"score_gpt":0.2340586858309545,"score_spread":0.2193477871915987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}