{"id":"W2086038769","doi":"10.1038/nrc2812","title":"PARP inhibition: PARP1 and beyond","year":2010,"lang":"en","type":"review","venue":"Nature reviews. Cancer","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":1311,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Université Laval","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health; National Institute of General Medical Sciences; Canada Research Chairs","keywords":"Limelight; PARP1; Poly ADP ribose polymerase; Polymerase; Biology; Computational biology; Enzyme; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007759602,0.001863029,0.002664626,0.001847888,0.0004155041,0.001574298,0.001575271,0.002099356,0.006043697],"category_scores_gemma":[0.0008254042,0.0004929547,0.0007357179,0.002395539,0.0008480658,0.002470253,0.001156695,0.005246961,0.00519629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001120011,"about_ca_system_score_gemma":0.0012288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001017126,"about_ca_topic_score_gemma":0.002515089,"domain_scores_codex":[0.9997357,0.00004414543,0.00002507736,0.00004322075,0.0001162463,0.00003578956],"domain_scores_gemma":[0.999592,0.0001640537,0.00005239017,0.00001391065,0.0001146811,0.00006300573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001921291,0.0001179549,0.00008485557,0.008467362,0.00007053126,0.0001752749,0.00003211963,0.0005251621,0.002257258,0.00387638,0.1362614,0.8479395],"study_design_scores_gemma":[0.0000543209,0.00009395033,0.0003307768,0.001803559,0.00006058686,0.0007419662,0.00003168896,0.0001145345,0.0003421958,0.002666947,0.9937388,0.00002062245],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004855331,0.9975747,0.0001476073,0.0006482736,0.000587645,0.000005732171,0.00002232571,0.00001209062,0.0009530195],"genre_scores_gemma":[0.000309167,0.997672,0.0001355414,0.0005589375,0.0003774644,0.000008238309,0.0000363599,0.000001839246,0.0009004751],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006043697,"threshold_uncertainty_score":0.02021819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04985341091087907,"score_gpt":0.4307639022885119,"score_spread":0.3809104913776328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}