{"id":"W2086065797","doi":"10.1523/jneurosci.0514-08.2008","title":"Estrogen Facilitates both Phosphatidylinositol 3-Kinase/Akt and ERK1/2 Mitogen-Activated Protein Kinase Membrane Signaling Required for Long-Term Neuropeptide Y Transcriptional Regulation in Clonal, Immortalized Neurons","year":2008,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network; Canada Research Chairs; University of Toronto","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Protein kinase B; Cell biology; Phosphatidylinositol; Kinase; Neuropeptide; Protein kinase A; Mitogen-activated protein kinase; Biology; Mitogen-activated protein kinase kinase; Estrogen; PI3K/AKT/mTOR pathway; MAP kinase kinase kinase; Signal transduction; Endocrinology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002735951,0.000224901,0.0002669473,0.0001386718,0.0002128221,0.00004428409,0.0002374305,0.0001178651,0.000002842869],"category_scores_gemma":[0.0002456622,0.0001989778,0.0001672533,0.000243733,0.0002621002,0.00006419313,0.00003426789,0.0002163117,4.463337e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001879259,"about_ca_system_score_gemma":0.0001759616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005118985,"about_ca_topic_score_gemma":0.000001247708,"domain_scores_codex":[0.9982429,0.0001613984,0.0005440335,0.0004055251,0.0003209266,0.0003251779],"domain_scores_gemma":[0.9991522,0.00004280164,0.0003253304,0.0001674305,0.0001335319,0.0001787423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009109614,0.000158488,0.004899375,0.00003649978,0.00001410738,0.0001765081,0.0000761451,0.0008029389,0.9926792,0.00002052642,0.00002386982,0.0002014214],"study_design_scores_gemma":[0.002036156,0.001488865,0.05759369,0.00007490261,0.0000274993,0.0006754054,0.000008598132,0.0003822261,0.9370683,0.00001556089,0.0004349171,0.0001939155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964211,0.001675006,0.0009095732,0.0001619518,0.0002691363,0.0005270823,0.0000209141,0.000009215587,0.000006009018],"genre_scores_gemma":[0.9987386,0.000295898,0.000525747,0.0001176776,0.00009603216,0.00001836933,0.00001826328,0.00002592347,0.0001635113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0556109,"threshold_uncertainty_score":0.8114081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02313359350162315,"score_gpt":0.2624835022577836,"score_spread":0.2393499087561604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}