{"id":"W2086065797","doi":"10.1523/jneurosci.0514-08.2008","title":"Estrogen Facilitates both Phosphatidylinositol 3-Kinase/Akt and ERK1/2 Mitogen-Activated Protein Kinase Membrane Signaling Required for Long-Term Neuropeptide Y Transcriptional Regulation in Clonal, Immortalized Neurons","year":2008,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network; Canada Research Chairs; University of Toronto","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Protein kinase B; Cell biology; Phosphatidylinositol; Kinase; Neuropeptide; Protein kinase A; Mitogen-activated protein kinase; Biology; Mitogen-activated protein kinase kinase; Estrogen; PI3K/AKT/mTOR pathway; MAP kinase kinase kinase; Signal transduction; Endocrinology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001433435,0.000195768,0.0002076222,0.0001243917,0.0001265979,0.0002059236,0.0001795966,0.00008621266,0.001252463],"category_scores_gemma":[0.0001240187,0.0001464184,0.0002272472,0.000102504,0.000146853,0.0001836528,0.0001998278,0.0003502813,0.0004043992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002712619,"about_ca_system_score_gemma":0.0002187544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007852038,"about_ca_topic_score_gemma":0.001938079,"domain_scores_codex":[0.9998509,0.00001424789,0.00001779861,0.00003163632,0.0000508773,0.00003456667],"domain_scores_gemma":[0.9999266,0.00001541554,0.00001730494,0.0000128276,0.00001067498,0.00001713943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007220953,0.00002327221,0.0001441985,0.00001359418,0.00000283393,0.00003637973,0.00002281147,0.00002035841,0.9987122,0.00006281251,0.00002319106,0.0008659976],"study_design_scores_gemma":[0.00002886483,0.0002817993,0.01393152,0.000009307393,0.00001586179,0.0003633957,0.0000521157,0.0007055804,0.9790548,0.00009769067,0.005454615,0.000004564215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938011,0.001345719,0.002257826,0.0000707399,0.00003133002,0.00003006514,0.0004850043,0.00004383774,0.001934489],"genre_scores_gemma":[0.9856716,0.001537131,0.003653554,0.00005358813,0.00001493403,0.00008369546,0.001596011,0.00002223915,0.007367231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001252463,"threshold_uncertainty_score":0.004189909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02313359350162315,"score_gpt":0.2624835022577836,"score_spread":0.2393499087561604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}