{"id":"W2086089050","doi":"10.1016/s0960-9822(00)00805-8","title":"The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo","year":2000,"lang":"en","type":"article","venue":"Current Biology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":240,"is_retracted":false,"has_abstract":false,"ca_institutions":"Terry Fox Research Institute; Ontario Institute for Cancer Research","funders":"National Institute on Aging","keywords":"Telomere; Telomerase; Biology; Telomerase reverse transcriptase; Telomerase RNA component; Genome instability; Reverse transcriptase; Molecular biology; Cell biology; Phenotype; Chromosome instability; RNA; Gene; Embryonic stem cell; Chromosome; Genetics; DNA; DNA damage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003699602,0.0002488389,0.0003692775,0.000147685,0.0002754101,0.00002476023,0.0001123001,0.000149066,0.0005155282],"category_scores_gemma":[0.0001322933,0.0001783811,0.0001160915,0.0002827838,0.0002950809,0.0001021673,0.0000178165,0.000315125,0.00002501629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004508507,"about_ca_system_score_gemma":0.00008108298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000591795,"about_ca_topic_score_gemma":0.00004042349,"domain_scores_codex":[0.9983122,0.0001016764,0.0004556171,0.0005009568,0.000101659,0.0005279051],"domain_scores_gemma":[0.9990799,0.0002887679,0.0000781128,0.0003074164,0.00006491037,0.0001808608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001497829,0.0002371102,0.03215672,0.0001992216,0.00004385306,0.00001490973,0.0006253599,9.600548e-7,0.01632398,0.0003332062,0.009415177,0.9391516],"study_design_scores_gemma":[0.004239629,0.0006906033,0.01718054,0.0002081467,0.0001400461,0.00007516504,0.0004860792,0.0005428871,0.004425815,0.000688819,0.9709505,0.0003718045],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807032,0.01352631,0.0001014386,0.003354,0.0008377567,0.0008426752,0.00017107,0.00007324665,0.0003902655],"genre_scores_gemma":[0.9860121,0.01033479,0.0001638706,0.001955109,0.0004363668,0.0001395535,0.00009355522,0.00003104605,0.0008335931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9615353,"threshold_uncertainty_score":0.727417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03146770495666072,"score_gpt":0.3033841022197786,"score_spread":0.2719163972631179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}