{"id":"W2086098426","doi":"10.1073/pnas.0405762101","title":"Mixing active-site components: A recipe for the unique enzymatic activity of a telomere resolvase","year":2004,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Tn3 transposon; Recombinase; Transposase; Biology; Telomere; DNA; Active site; Nuclease; Binding site; Mutant; Biochemistry; Genetics; Enzyme; Transposable element; Recombination; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005698273,0.00006590433,0.00009435065,0.00004593188,0.0001060091,0.000006599694,0.0003821936,0.00005812027,9.8316e-7],"category_scores_gemma":[0.0003856785,0.00004095049,0.00007630431,0.0002142485,0.0003058045,0.00001347076,0.00009406058,0.00006785122,7.333865e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001242885,"about_ca_system_score_gemma":0.00002914555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001018169,"about_ca_topic_score_gemma":3.459098e-7,"domain_scores_codex":[0.9992965,0.000003393397,0.0001591315,0.0001401371,0.0003039998,0.00009681741],"domain_scores_gemma":[0.9995447,0.00006456227,0.0002046749,0.00001244765,0.0001567753,0.00001681844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003840446,0.00002785558,0.000211673,0.00006761131,0.00001994758,8.961705e-10,0.0001160509,0.001411969,0.9958439,0.001815401,0.00004805713,0.0003991445],"study_design_scores_gemma":[0.000215895,0.00006349866,0.01467407,0.00007274582,0.00001215196,0.000003029894,0.00009334619,0.0006196619,0.9807702,0.00321767,0.0002098866,0.00004782908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977725,0.0002124301,0.0003030947,0.001141219,0.00001317246,0.0002272106,0.00002292573,0.000002337255,0.0003051088],"genre_scores_gemma":[0.9972,0.00004438415,0.002609997,0.00005719288,0.00004401248,0.00001618129,2.685003e-7,0.000003490608,0.00002449611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01507367,"threshold_uncertainty_score":0.1669913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03176403389846679,"score_gpt":0.3325436098629679,"score_spread":0.3007795759645012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}