{"id":"W2086201901","doi":"10.1002/hep.23330","title":"Acetaminophen Dosing of Humans Results in Blood Transcriptome and Metabolome Changes Consistent With Impaired Oxidative Phosphorylation","year":2009,"lang":"en","type":"article","venue":"Hepatology","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Chenomx (Canada)","funders":"National Institute of Environmental Health Sciences; National Center for Research Resources; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Metabolome; Oxidative phosphorylation; Transcriptome; Dosing; Acetaminophen; Pharmacology; Phosphorylation; Chemistry; Metabolite; Medicine; Biochemistry; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000125111,0.0003789421,0.0002670453,0.0002352748,0.0001744688,0.0002427197,0.00009063327,0.0002915034,0.001386766],"category_scores_gemma":[0.0002927124,0.0001531665,0.0001799575,0.0002642306,0.0002270525,0.0001266717,0.0001641172,0.0003307308,0.0002465658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001737069,"about_ca_system_score_gemma":0.0001351297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004978037,"about_ca_topic_score_gemma":0.0007201003,"domain_scores_codex":[0.9998542,0.00002497395,0.000008924443,0.000045929,0.00004950675,0.00001648486],"domain_scores_gemma":[0.999783,0.0000291321,0.0001178067,0.00001796702,0.00002353008,0.00002869062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002239723,0.0001136633,0.03682678,0.0001023235,0.00008297525,0.0003538073,0.00005979749,0.000121158,0.9505733,0.00002976877,0.0002452796,0.009251435],"study_design_scores_gemma":[0.00003596262,0.002316004,0.7823269,0.00002158549,0.0001407376,0.001594702,0.0001816984,0.0009196667,0.2106005,0.0001346229,0.001714434,0.00001323498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964498,0.0009156904,0.00134337,0.0001520108,0.00002156931,0.00002579766,0.0005876522,0.00004212989,0.0004619116],"genre_scores_gemma":[0.9961845,0.0007583889,0.001323986,0.0001954428,0.00002106423,0.00004060689,0.00067311,0.00001038205,0.000792576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001386766,"threshold_uncertainty_score":0.004639208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09354386124845877,"score_gpt":0.3644132617526492,"score_spread":0.2708694005041904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}