{"id":"W2086210103","doi":"10.1021/bi035492h","title":"Structural Comparison of MTA Phosphorylase and MTA/AdoHcy Nucleosidase Explains Substrate Preferences and Identifies Regions Exploitable for Inhibitor Design","year":2004,"lang":"en","type":"article","venue":"Biochemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Substrate (aquarium); Chemistry; Glycogen phosphorylase; Substrate specificity; Stereochemistry; Biochemistry; Enzyme; Biology; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001155774,0.000222207,0.0002374325,0.00002716949,0.0001445969,0.00005951217,0.0001889909,0.0002494812,0.000005788887],"category_scores_gemma":[0.0001535615,0.0002058807,0.00007743294,0.00007298323,0.0003893407,0.00001046692,0.0001719156,0.0001167962,6.225135e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001422263,"about_ca_system_score_gemma":0.0001176459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003021305,"about_ca_topic_score_gemma":0.000009105363,"domain_scores_codex":[0.9987038,0.00002408109,0.0002845832,0.0005101204,0.0001579527,0.0003194119],"domain_scores_gemma":[0.9992412,0.00002524019,0.0001099059,0.0003030818,0.0001282928,0.0001922586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000226343,0.00007189903,0.0003814648,0.0002117135,0.00005054194,0.000002121056,0.00008221345,0.00001420678,0.99759,0.00005294033,0.0009456588,0.0003709149],"study_design_scores_gemma":[0.00106038,0.0002680717,0.0002056434,0.00007044427,0.00003029292,0.00001856026,0.0004733005,0.00004454015,0.996681,0.0006673069,0.0002353741,0.0002450631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993085,0.004535155,0.001715568,0.0001585463,0.0000416166,0.0003207915,0.00008591205,0.00001417704,0.00004321632],"genre_scores_gemma":[0.9971168,0.0003089691,0.002004751,0.00003279404,0.00008947522,0.00006481108,0.0001683327,0.0000230043,0.0001910607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004226186,"threshold_uncertainty_score":0.8395571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04533554212369763,"score_gpt":0.3047101445320822,"score_spread":0.2593746024083846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}