{"id":"W2086210103","doi":"10.1021/bi035492h","title":"Structural Comparison of MTA Phosphorylase and MTA/AdoHcy Nucleosidase Explains Substrate Preferences and Identifies Regions Exploitable for Inhibitor Design","year":2004,"lang":"en","type":"article","venue":"Biochemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Substrate (aquarium); Chemistry; Glycogen phosphorylase; Substrate specificity; Stereochemistry; Biochemistry; Enzyme; Biology; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001341601,0.0004210247,0.0003810766,0.0002060756,0.0001694898,0.0004967817,0.0003747524,0.000436569,0.001150412],"category_scores_gemma":[0.0002802366,0.000178835,0.00036743,0.0002656036,0.000178661,0.0003254516,0.0001552892,0.0005310524,0.000385075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004968934,"about_ca_system_score_gemma":0.0002912795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001202696,"about_ca_topic_score_gemma":0.0009424399,"domain_scores_codex":[0.9999095,0.00001337316,0.000005611944,0.00002167088,0.00003143103,0.00001829784],"domain_scores_gemma":[0.9999,0.00001987371,0.00002544795,0.000007952772,0.00001627873,0.00003043604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005235936,0.00005037131,0.002381741,0.0001556919,0.00003052864,0.0004842852,0.00005230858,0.00297604,0.9834988,0.00131771,0.0002339007,0.008295117],"study_design_scores_gemma":[0.000100348,0.0007915742,0.01901368,0.0000397224,0.00008602292,0.002511602,0.0001708487,0.03126214,0.9234504,0.0009727267,0.02154968,0.00005119038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980283,0.006685864,0.007531574,0.0001785188,0.000036857,0.00003618496,0.0005739019,0.0001874656,0.004486672],"genre_scores_gemma":[0.988893,0.00184359,0.006141953,0.0000804732,0.00001018088,0.00002174427,0.001553829,0.00003759396,0.001417698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001202696,"threshold_uncertainty_score":0.003848493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04533554212369763,"score_gpt":0.3047101445320822,"score_spread":0.2593746024083846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}