{"id":"W2086222405","doi":"10.1194/jlr.m030528","title":"AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism","year":2012,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":236,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"ATP citrate lyase; Biochemistry; Adenylate kinase; Chemistry; Lipid metabolism; Fatty acid synthesis; Protein kinase A; AMP-activated protein kinase; Kinase; Fatty acid; Enzyme; AMPK; Citrate synthase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001994209,0.0002624397,0.0005497136,0.0002303175,0.0001298921,0.00006335614,0.0002674465,0.0001908207,0.00001761207],"category_scores_gemma":[0.0007082348,0.0002162596,0.0001829378,0.0002535056,0.0002905263,0.00003037438,0.0001922041,0.0003754291,7.305966e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002535897,"about_ca_system_score_gemma":0.0002316827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003485656,"about_ca_topic_score_gemma":0.00001141084,"domain_scores_codex":[0.9976103,0.0003114384,0.0005669259,0.0003339935,0.0004814347,0.0006958494],"domain_scores_gemma":[0.9976588,0.00005535224,0.0004668587,0.0003562995,0.0009648117,0.0004978953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006974951,0.0002517732,0.0004709697,0.0002173563,0.0002132541,0.000004845989,0.0001525393,0.00001005782,0.9949416,0.0001316142,0.0003176843,0.002590799],"study_design_scores_gemma":[0.002527277,0.0003270891,0.002249763,0.000112688,0.00006710883,0.00002231846,0.00008056298,0.0000445137,0.9113268,0.00006778737,0.08294252,0.0002315889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9026747,0.09560031,0.0007037893,0.0001325699,0.0002000976,0.0005392051,0.00009331151,0.000003834604,0.0000521767],"genre_scores_gemma":[0.993229,0.002623673,0.002444216,0.00008345569,0.001323751,0.00006979623,0.00002018513,0.0000607348,0.0001451875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09297663,"threshold_uncertainty_score":0.881881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04534888364129872,"score_gpt":0.3284215907368723,"score_spread":0.2830727070955736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}