{"id":"W2086240368","doi":"10.1002/pro.2135","title":"Exploration of the active site of <i>Escherichia coli</i> cystathionine γ‐synthase","year":2012,"lang":"en","type":"article","venue":"Protein Science","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cystathionine beta synthase; Active site; Chemistry; Escherichia coli; Cysteine; Stereochemistry; Biochemistry; Enzyme; Residue (chemistry); Binding site; Substrate (aquarium); Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007691901,0.00005222302,0.0001100538,0.00007026732,0.00008662889,0.0000064925,0.0001498522,0.00002439386,0.0000359668],"category_scores_gemma":[0.0004555091,0.00003120983,0.00003446284,0.000989678,0.0005681099,0.0005853801,0.00009506432,0.0001095642,0.00001385783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000352911,"about_ca_system_score_gemma":0.000247679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000071423,"about_ca_topic_score_gemma":0.000003623583,"domain_scores_codex":[0.998852,0.00003796877,0.0001438788,0.0001111691,0.0006406004,0.0002143486],"domain_scores_gemma":[0.999259,0.00002279084,0.00009230558,0.0002720721,0.0002636194,0.00009022852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007345197,0.0001419024,0.002054994,0.00004231512,0.00000332017,3.445906e-7,0.001354457,0.000001557431,0.9935842,0.0003441735,0.00001866942,0.002380583],"study_design_scores_gemma":[0.0002504386,0.0001698027,0.02930801,0.00007648819,0.000007886016,0.000001761734,0.0002164236,0.000177938,0.9692684,0.00004548618,0.0004441302,0.00003322902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963898,0.00008451128,0.000335171,0.0005246914,0.00004903295,0.0005782628,0.000005950562,0.000006480396,0.002026087],"genre_scores_gemma":[0.9984912,0.000007212697,0.0009245625,0.00004420278,0.0000301509,0.00003041408,7.958827e-7,0.000004029611,0.0004674183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02725301,"threshold_uncertainty_score":0.2093225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04448614321676808,"score_gpt":0.3264779657316828,"score_spread":0.2819918225149147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}