{"id":"W2086264558","doi":"10.1042/ba20020028","title":"Modified high amylose starch for immobilization of uricase for therapeutic application","year":2002,"lang":"en","type":"article","venue":"Biotechnology and Applied Biochemistry","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Agarose; Sepharose; Yield (engineering); Chromatography; Urate oxidase; Enzyme; Starch; Substrate (aquarium); Immobilized enzyme; Reagent; Amylose; Modified starch; Biochemistry; Nuclear chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001688364,0.0005131486,0.0003381138,0.0001857369,0.00005867586,0.0002331692,0.00026458,0.0003746775,0.0006831364],"category_scores_gemma":[0.0001152103,0.0001564614,0.000351967,0.0001848663,0.00009948287,0.0001259165,0.0001878349,0.0003690038,0.0002950122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001509214,"about_ca_system_score_gemma":0.00009825191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002399745,"about_ca_topic_score_gemma":0.0002302952,"domain_scores_codex":[0.9998387,0.0000283527,0.00001501178,0.00004033515,0.00005093572,0.00002660753],"domain_scores_gemma":[0.9999548,0.00000757791,0.00001302294,0.000005559429,0.000008485528,0.00001058358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001100473,0.000002978181,0.00002143364,0.00001624772,0.000003240693,0.00001256875,0.000002559204,0.00001671015,0.9992626,0.00001177461,0.000004437371,0.0006344588],"study_design_scores_gemma":[0.000004987624,0.0001856921,0.001071362,0.000005666744,0.00002260836,0.0002514691,0.00000476069,0.0006365079,0.9960678,0.0000173717,0.001727389,0.00000453247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9572411,0.007973794,0.03273262,0.00009370446,0.00007033014,0.00006730857,0.0001422533,0.0002659974,0.001412906],"genre_scores_gemma":[0.9727632,0.00229976,0.02172105,0.00006557227,0.0000193288,0.00004809541,0.0005470501,0.00003637218,0.002499437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006831364,"threshold_uncertainty_score":0.002285302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01729774603220832,"score_gpt":0.2492261017083029,"score_spread":0.2319283556760946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}