{"id":"W2086264558","doi":"10.1042/ba20020028","title":"Modified high amylose starch for immobilization of uricase for therapeutic application","year":2002,"lang":"en","type":"article","venue":"Biotechnology and Applied Biochemistry","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Agarose; Sepharose; Yield (engineering); Chromatography; Urate oxidase; Enzyme; Starch; Substrate (aquarium); Immobilized enzyme; Reagent; Amylose; Modified starch; Biochemistry; Nuclear chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009392128,0.0001491822,0.0002593206,0.00006797291,0.00007243447,0.000003706553,0.00009976399,0.0006257279,0.00001101838],"category_scores_gemma":[0.00003747443,0.0001367849,0.0000502621,0.0001830146,0.0002324582,0.00001120384,0.00003293027,0.0001319808,0.000001924929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003432707,"about_ca_system_score_gemma":0.00001905747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002579074,"about_ca_topic_score_gemma":1.316392e-7,"domain_scores_codex":[0.9990906,0.000002917229,0.0002434049,0.0003789593,0.00008181758,0.0002023204],"domain_scores_gemma":[0.9993037,0.00006980137,0.0001287561,0.0003939056,0.00005583212,0.00004800713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000308046,0.0002244323,0.00005571274,0.0004209838,0.00006997087,3.311372e-7,0.00002755885,0.00000477922,0.9728464,0.006360118,0.0001401443,0.01954156],"study_design_scores_gemma":[0.002018079,0.0002207991,0.00006504435,0.00001325447,0.0001668809,0.00002214252,0.0001101436,0.002517309,0.9911212,0.001741316,0.001868674,0.0001351322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9566506,0.0008723728,0.03855009,0.002049196,0.00001706756,0.001415189,0.00006737065,0.0001376554,0.0002404137],"genre_scores_gemma":[0.9932491,0.0001608202,0.005553416,0.0001380158,0.00005508154,0.0005464045,0.0001393237,0.00002169643,0.0001361103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03659849,"threshold_uncertainty_score":0.5577928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01729774603220832,"score_gpt":0.2492261017083029,"score_spread":0.2319283556760946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}