{"id":"W2086267542","doi":"10.1016/j.cellsig.2007.02.001","title":"Novel dominant negative Smad antagonists to TGFβ signaling","year":2007,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"National Cancer Institute; China Scholarship Council; Canadian Institutes of Health Research; Terry Fox Foundation","keywords":"Phosphorylation; SMAD; Cell biology; Mutant; Signal transduction; Smad2 Protein; Biology; Serine; R-SMAD; Alanine; Kinase; Receptor; Chemistry; Biochemistry; Endoglin; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007997898,0.000360541,0.0002780766,0.000139971,0.0002805429,0.00008098964,0.0004617464,0.0002172383,0.00005724655],"category_scores_gemma":[0.0002390794,0.0003762525,0.0001981842,0.0002496966,0.00009570758,0.000007823333,0.0001904208,0.0001802348,0.00009099345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005242717,"about_ca_system_score_gemma":0.0001437616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003796418,"about_ca_topic_score_gemma":0.00002935503,"domain_scores_codex":[0.9976105,0.0000458984,0.0005243111,0.0007486019,0.0003456258,0.0007250594],"domain_scores_gemma":[0.9986885,0.00009520336,0.000165099,0.0004442825,0.0002022487,0.000404692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000259512,0.0001444993,0.0003070493,0.00003284385,0.00007900892,0.00005552958,0.0002759295,0.002861674,0.9947498,0.0000732241,0.0001608856,0.000999994],"study_design_scores_gemma":[0.0006559212,0.0001842332,0.0001474562,0.00009152733,0.00004295828,0.00001250872,0.0002363822,0.0001411077,0.9854391,0.00004776169,0.01248796,0.0005130628],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.610263,0.0007171886,0.388043,0.00002568166,0.0002197453,0.0002744306,0.00001285662,0.00003399262,0.0004099839],"genre_scores_gemma":[0.9761986,0.000007480542,0.0217618,0.0004166123,0.000872437,0.00002151845,0.0001156171,0.00008393905,0.0005220005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3662812,"threshold_uncertainty_score":0.9998689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01418407592181369,"score_gpt":0.2556353690284523,"score_spread":0.2414512931066386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}