{"id":"W2086267542","doi":"10.1016/j.cellsig.2007.02.001","title":"Novel dominant negative Smad antagonists to TGFβ signaling","year":2007,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"National Cancer Institute; China Scholarship Council; Canadian Institutes of Health Research; Terry Fox Foundation","keywords":"Phosphorylation; SMAD; Cell biology; Mutant; Signal transduction; Smad2 Protein; Biology; Serine; R-SMAD; Alanine; Kinase; Receptor; Chemistry; Biochemistry; Endoglin; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004716505,0.0007514642,0.0004711984,0.0005276469,0.0003295939,0.0007266115,0.000659912,0.0004447253,0.003446602],"category_scores_gemma":[0.0002572889,0.0003623453,0.0004480437,0.0001910194,0.0003264358,0.000233956,0.000217774,0.001537596,0.0009974013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004582312,"about_ca_system_score_gemma":0.0003049928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003467615,"about_ca_topic_score_gemma":0.001378651,"domain_scores_codex":[0.9997736,0.00004302835,0.00001847253,0.00002473447,0.00008285314,0.00005739272],"domain_scores_gemma":[0.9998449,0.00004677261,0.0000298483,0.00001726891,0.00002654631,0.00003468084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002928391,0.00007288799,0.00008827459,0.00006744896,0.00002248295,0.0001262173,0.00001522536,0.0002002955,0.9917884,0.001594998,0.0003938269,0.005337182],"study_design_scores_gemma":[0.0002770266,0.0005741264,0.0005938645,0.00001794911,0.0001192639,0.001346748,0.00003702657,0.002754166,0.9697574,0.0004542229,0.02404998,0.00001815598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8799272,0.02400448,0.06300844,0.002075115,0.001196879,0.0005029335,0.001506207,0.001090816,0.02668803],"genre_scores_gemma":[0.9450971,0.01061659,0.02669892,0.0007035447,0.000210604,0.0002457879,0.001079869,0.0001393514,0.01520829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003446602,"threshold_uncertainty_score":0.01153004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01418407592181369,"score_gpt":0.2556353690284523,"score_spread":0.2414512931066386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}