{"id":"W2086273007","doi":"10.1038/nn.3286","title":"How do environments talk to genes?","year":2012,"lang":"en","type":"letter","venue":"Nature Neuroscience","topic":"Birth, Development, and Health","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Neuroscience; Regulator; Fight-or-flight response; Mechanism (biology); Gene; FKBP5; Glucocorticoid; Traumatic stress; Allele; Biology; Genetics; Psychology; Glucocorticoid receptor; Psychiatry; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003456065,0.0008407691,0.001499584,0.0005501767,0.003270244,0.002668545,0.001374895,0.02982781,0.005095586],"category_scores_gemma":[0.01467654,0.0006232754,0.001026867,0.0004329873,0.004583355,0.004167099,0.001883549,0.04592393,0.004291127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002514803,"about_ca_system_score_gemma":0.00244772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005936931,"about_ca_topic_score_gemma":0.01290357,"domain_scores_codex":[0.9983584,0.0005811384,0.0001509183,0.0002690826,0.0004469746,0.0001934246],"domain_scores_gemma":[0.9919171,0.005918379,0.000352259,0.0002267759,0.0008108875,0.0007746067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002070668,0.00006766521,0.001178085,0.0001073964,0.00005119972,0.001454711,0.0002957159,0.0001252951,0.0003635938,0.00954633,0.9504744,0.03612854],"study_design_scores_gemma":[0.000267279,0.0001039417,0.00236917,0.0003697208,0.0000767112,0.001670224,0.0008626998,0.0005712398,0.0004965572,0.04532618,0.9477811,0.0001050356],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0002161765,0.002291906,0.0001189505,0.987282,0.00914673,0.000002469573,0.00002238261,0.00001370051,0.0009057288],"genre_scores_gemma":[0.005299882,0.004528666,0.0003132113,0.9408294,0.04431579,0.0000257528,0.00001957225,0.00002157772,0.004646254],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02982781,"threshold_uncertainty_score":0.01827765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0224663495186162,"score_gpt":0.2837777685375686,"score_spread":0.2613114190189524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}