{"id":"W2086273007","doi":"10.1038/nn.3286","title":"How do environments talk to genes?","year":2012,"lang":"en","type":"letter","venue":"Nature Neuroscience","topic":"Birth, Development, and Health","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Neuroscience; Regulator; Fight-or-flight response; Mechanism (biology); Gene; FKBP5; Glucocorticoid; Traumatic stress; Allele; Biology; Genetics; Psychology; Glucocorticoid receptor; Psychiatry; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0002071662,0.0003886781,0.0004304557,0.0002654017,0.0001916893,0.0001090581,0.0005139858,0.001435192,0.00005179195],"category_scores_gemma":[0.0001775011,0.0003141418,0.0000982171,0.0004134816,0.000150791,0.0001541149,0.0001777389,0.004480711,0.0001329725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001799788,"about_ca_system_score_gemma":0.0002393102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002827898,"about_ca_topic_score_gemma":9.790506e-7,"domain_scores_codex":[0.9965013,0.00005335817,0.0002095946,0.0009418583,0.001339628,0.0009542342],"domain_scores_gemma":[0.9986297,0.00003354352,0.0001551105,0.0007172379,0.00003024131,0.0004341757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001254362,0.0000479078,0.00160489,0.0001807842,0.000003656841,0.0005615043,0.00006510238,1.590126e-7,0.01964039,0.0001536486,0.9750922,0.00263718],"study_design_scores_gemma":[0.00021436,0.0001244239,0.02339522,0.00007300793,0.00002743875,0.0002508218,0.000004159025,0.000001577556,0.001745294,0.00008090065,0.9737996,0.0002831819],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.002982953,0.001947291,0.0002402637,0.9831165,0.007168432,0.001038889,0.0000522999,0.00008530242,0.003368065],"genre_scores_gemma":[0.02051357,0.006559653,0.0008478566,0.9596678,0.004224209,0.00003390814,0.00004314978,0.00006341857,0.008046452],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02344872,"threshold_uncertainty_score":0.999931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0224663495186162,"score_gpt":0.2837777685375686,"score_spread":0.2613114190189524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}