{"id":"W2086314936","doi":"10.1371/journal.pone.0069089","title":"Phenotypic Switching Induced by Damaged Matrix Is Associated with DNA Methyltransferase 3A (DNMT3A) Activity and Nuclear Localization in Smooth Muscle Cells (SMC)","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"DNA methylation; Extracellular matrix; Epigenetics; Biology; Cell biology; Methyltransferase; CpG site; Nuclear matrix; Methylation; Molecular biology; Gene expression; DNA; Chemistry; Genetics; Chromatin; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001424749,0.0001715766,0.0001795487,0.0002018223,0.0001485953,0.0002273156,0.0001021732,0.0001820358,0.00122854],"category_scores_gemma":[0.0001281198,0.0002060931,0.0001751099,0.0001659691,0.0002008907,0.0001097718,0.0002373285,0.0003655161,0.0001870979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002020514,"about_ca_system_score_gemma":0.0001645834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008565591,"about_ca_topic_score_gemma":0.002026219,"domain_scores_codex":[0.9998302,0.00002451904,0.00001281336,0.00005304965,0.00004752216,0.00003176046],"domain_scores_gemma":[0.9998748,0.0000153274,0.0000491195,0.00001455716,0.00001635217,0.00002982899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003351317,0.00000384254,0.0003770007,0.000009073101,0.000002420097,0.00001531282,0.000009147742,0.000006853401,0.9991238,0.00002220822,0.00001060309,0.0003864038],"study_design_scores_gemma":[0.00000646717,0.0001823565,0.05811207,0.000006010213,0.00001710774,0.0003275689,0.00004272918,0.0005428393,0.9388673,0.00008268486,0.001807634,0.00000531627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936801,0.001834617,0.002807573,0.00009314075,0.00002113952,0.00001590314,0.0005409012,0.00006308388,0.0009435373],"genre_scores_gemma":[0.9952166,0.0007129346,0.001653268,0.00003240478,0.000006215507,0.00002165004,0.000418586,0.00001329289,0.001925088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00122854,"threshold_uncertainty_score":0.004109859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01535649904435779,"score_gpt":0.2168208902200831,"score_spread":0.2014643911757253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}