{"id":"W2086342381","doi":"10.1371/journal.pone.0015535","title":"Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":224,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Ontario Genomics; National Institutes of Health; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Commonwealth Scholarship Commission; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; National Human Genome Research Institute; Wellcome Trust","keywords":"Demethylase; Histone; Epigenetics; Small molecule; Histone methyltransferase; Methyltransferase; Biology; Computational biology; Histone methylation; High-throughput screening; Biochemistry; Drug discovery; Methylation; DNA methylation; Gene expression; DNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005417955,0.0007158458,0.00071406,0.0006609729,0.0001995474,0.0005083871,0.0006528865,0.0004409065,0.001788372],"category_scores_gemma":[0.0003824969,0.0001889846,0.0004741708,0.000607648,0.0002301213,0.0002466807,0.0002903958,0.0004915953,0.0006843038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004984841,"about_ca_system_score_gemma":0.0003466648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005568709,"about_ca_topic_score_gemma":0.001679134,"domain_scores_codex":[0.9996495,0.0000529182,0.00002252194,0.0000708325,0.0001529549,0.00005114388],"domain_scores_gemma":[0.9997676,0.00006897477,0.00003863821,0.00002552084,0.00006667844,0.00003262279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000368412,0.0004680547,0.001219261,0.0002068511,0.00006356111,0.00009492614,0.0000293763,0.001626537,0.9811388,0.0001200627,0.0004324893,0.01423176],"study_design_scores_gemma":[0.0001980489,0.004810665,0.006865953,0.00002737791,0.0001784787,0.0005072616,0.00004683158,0.005663944,0.9744543,0.0001372448,0.007080809,0.00002906569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9504936,0.01025128,0.02743695,0.0003648094,0.00007867876,0.001107086,0.003530948,0.0009072133,0.005829446],"genre_scores_gemma":[0.9643947,0.005401785,0.01998905,0.0002660743,0.00003296899,0.000452709,0.004938361,0.00006066903,0.004463793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001788372,"threshold_uncertainty_score":0.005982697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02934464999008691,"score_gpt":0.282602469883072,"score_spread":0.2532578198929851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}