{"id":"W2086342381","doi":"10.1371/journal.pone.0015535","title":"Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":224,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Ontario Genomics; National Institutes of Health; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Commonwealth Scholarship Commission; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; National Human Genome Research Institute; Wellcome Trust","keywords":"Demethylase; Histone; Epigenetics; Small molecule; Histone methyltransferase; Methyltransferase; Biology; Computational biology; Histone methylation; High-throughput screening; Biochemistry; Drug discovery; Methylation; DNA methylation; Gene expression; DNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002142108,0.0002230623,0.0002404755,0.00008969266,0.0001748126,0.00004552898,0.000180043,0.000243842,0.00007156565],"category_scores_gemma":[0.0004042085,0.0002346335,0.00009007936,0.0001327735,0.0001635593,0.00001525849,0.0001390353,0.000253107,0.00006611397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001201076,"about_ca_system_score_gemma":0.00006114243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002359831,"about_ca_topic_score_gemma":0.0001982184,"domain_scores_codex":[0.998538,0.00007749013,0.0003073387,0.0004839798,0.0003078254,0.0002854031],"domain_scores_gemma":[0.9989449,0.00005189834,0.0001974841,0.0004005375,0.0002833992,0.0001217669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000106585,0.0004482998,0.0006154212,0.00003401618,0.0001395343,0.00000379981,0.0001586143,0.00004055591,0.9974252,0.0001625074,0.00008657118,0.0007789092],"study_design_scores_gemma":[0.0004700386,0.0004592935,0.001206649,0.00002802444,0.000095514,6.726768e-7,0.0001324033,0.0001596959,0.9955955,0.0007477683,0.000810497,0.0002939401],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949788,0.001309313,0.001733007,0.0002025756,0.0002760826,0.0002546559,0.0000352459,0.00003251118,0.001177795],"genre_scores_gemma":[0.9765832,0.0003903075,0.02075058,0.00007708204,0.0005154096,0.00003768015,0.0002366338,0.00004693264,0.001362151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01901758,"threshold_uncertainty_score":0.9568074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02934464999008691,"score_gpt":0.282602469883072,"score_spread":0.2532578198929851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}