{"id":"W2086391714","doi":"10.1016/j.molonc.2013.01.001","title":"Profiling pathway‐specific novel therapeutics in preclinical assessment for central nervous system atypical teratoid rhabdoid tumors (CNS ATRT): Favorable activity of targeting EGFR‐ ErbB2 signaling with lapatinib","year":2013,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Children's Hospital Foundation; Brain Tumour Foundation of Canada; American College Health Foundation; Children's Hospital Foundation","keywords":"Lapatinib; Cancer research; In vivo; PI3K/AKT/mTOR pathway; Pharmacology; Chemical library; Biology; Medicine; Signal transduction; Cancer; Small molecule; Internal medicine; Cell biology; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005076178,0.0002870409,0.0005572218,0.00005638024,0.00008989767,0.00003393086,0.000247373,0.0003600152,0.000008557709],"category_scores_gemma":[0.00005192875,0.0002525926,0.0001765802,0.0001326887,0.0001171967,0.00001071654,0.00009879481,0.0003124174,0.000001373629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002161805,"about_ca_system_score_gemma":0.0006135492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006197139,"about_ca_topic_score_gemma":0.00003030866,"domain_scores_codex":[0.997682,0.0002303407,0.0006485875,0.0006254561,0.0002167271,0.0005968622],"domain_scores_gemma":[0.9988158,0.0001197935,0.0003512267,0.0003583179,0.0002387583,0.0001161264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004363707,0.00039548,0.003170342,0.0001816854,0.00009506102,0.00001097237,0.00007240112,0.01224504,0.9765899,0.0001900304,0.0000224345,0.006590269],"study_design_scores_gemma":[0.003266083,0.002259979,0.00201037,0.0001982608,0.00005067119,0.00004019396,0.00046746,0.04444538,0.9449106,0.00003385685,0.001850526,0.0004665738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8693918,0.0003750231,0.128536,0.000119741,0.0001642773,0.00116339,0.00002953085,0.00002548151,0.0001946985],"genre_scores_gemma":[0.9460592,0.00002032607,0.05307326,0.0001218199,0.0001556603,0.0003929321,0.0001044616,0.00005698605,0.00001539641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07666734,"threshold_uncertainty_score":0.9999926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02494182689789846,"score_gpt":0.3069187082202217,"score_spread":0.2819768813223232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}