{"id":"W2086391714","doi":"10.1016/j.molonc.2013.01.001","title":"Profiling pathway‐specific novel therapeutics in preclinical assessment for central nervous system atypical teratoid rhabdoid tumors (CNS ATRT): Favorable activity of targeting EGFR‐ ErbB2 signaling with lapatinib","year":2013,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Children's Hospital Foundation; Brain Tumour Foundation of Canada; American College Health Foundation; Children's Hospital Foundation","keywords":"Lapatinib; Cancer research; In vivo; PI3K/AKT/mTOR pathway; Pharmacology; Chemical library; Biology; Medicine; Signal transduction; Cancer; Small molecule; Internal medicine; Cell biology; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003548143,0.0005402422,0.0005012521,0.0006749539,0.0001571891,0.0005403159,0.0002303892,0.0002545774,0.001811105],"category_scores_gemma":[0.0002041531,0.0001757905,0.0003732661,0.0004149412,0.0001401113,0.0003167741,0.0001770233,0.000541084,0.0004596029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002799055,"about_ca_system_score_gemma":0.0004802581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003911675,"about_ca_topic_score_gemma":0.00152926,"domain_scores_codex":[0.9998679,0.0000223334,0.000009053936,0.00002483708,0.0000449341,0.00003089822],"domain_scores_gemma":[0.9999075,0.0000166842,0.00002280924,0.000007337973,0.00002294413,0.00002277893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003743783,0.0004507192,0.001294684,0.0001987029,0.00002881558,0.00009377911,0.00002732008,0.001807923,0.9780872,0.00009813572,0.0001997942,0.01733847],"study_design_scores_gemma":[0.0001297033,0.01234132,0.009537256,0.00003669552,0.000189406,0.0006886368,0.00006794008,0.003905657,0.966685,0.0001411801,0.006253758,0.00002337036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814227,0.005253945,0.006534956,0.0001382294,0.00002147332,0.0005526225,0.002071873,0.000191878,0.003812281],"genre_scores_gemma":[0.9722012,0.008154517,0.01170358,0.0001352644,0.00001257398,0.0003416229,0.003539185,0.0000552354,0.003856863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001811105,"threshold_uncertainty_score":0.006058812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02494182689789846,"score_gpt":0.3069187082202217,"score_spread":0.2819768813223232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}