{"id":"W2086498377","doi":"10.1056/nejmoa1412965","title":"Improvement and Decline in Vision with Gene Therapy in Childhood Blindness","year":2015,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":377,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Eye Institute","keywords":"Medicine; Blindness; Childhood blindness; Retina; Genetic enhancement; Ophthalmology; Retinal; Pediatrics; Optometry; Gene; Retinopathy of prematurity; Genetics; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000327309,0.0001216273,0.000210035,0.0002635638,0.0002147693,0.0002770633,0.00008646707,0.0002912928,0.0006832913],"category_scores_gemma":[0.0003287995,0.00004782861,0.0001515152,0.0002665803,0.0003858769,0.0001493563,0.0001273812,0.000329456,0.0001312586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005832068,"about_ca_system_score_gemma":0.0002592326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00180865,"about_ca_topic_score_gemma":0.001984507,"domain_scores_codex":[0.999897,0.00003258466,0.000006724982,0.00001040436,0.0000287003,0.00002463657],"domain_scores_gemma":[0.9998993,0.00002537046,0.00003874913,0.000008168658,0.000009223848,0.00001929363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007772553,0.001507962,0.2073756,0.0006881754,0.0002494544,0.01574714,0.001000534,0.002454401,0.3921336,0.004218766,0.004600575,0.3622513],"study_design_scores_gemma":[0.0003822235,0.01004273,0.8261203,0.00009265183,0.0001968035,0.04005897,0.0002631227,0.001606999,0.1055378,0.001081354,0.01457305,0.00004391464],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890837,0.005209341,0.0008287744,0.0003037644,0.000009735519,0.00002159421,0.0001436133,0.0000560853,0.004343221],"genre_scores_gemma":[0.9981478,0.0009544113,0.0002798435,0.00004365598,0.000003432689,0.000007997096,0.00008424828,0.000003535569,0.0004749639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00180865,"threshold_uncertainty_score":0.004231453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01036036072775383,"score_gpt":0.2617443459305269,"score_spread":0.2513839852027731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}