{"id":"W2086498377","doi":"10.1056/nejmoa1412965","title":"Improvement and Decline in Vision with Gene Therapy in Childhood Blindness","year":2015,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":377,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Eye Institute","keywords":"Medicine; Blindness; Childhood blindness; Retina; Genetic enhancement; Ophthalmology; Retinal; Pediatrics; Optometry; Gene; Retinopathy of prematurity; Genetics; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006095823,0.00007991558,0.0001550144,0.0000927483,0.00000722605,0.000004880242,0.00006590156,0.00003934476,0.00000488255],"category_scores_gemma":[0.00006776086,0.00004633811,0.000009570239,0.00008058754,0.00003228997,0.0000047758,0.00002052603,0.00008737108,1.404163e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007863161,"about_ca_system_score_gemma":0.0001325368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005888766,"about_ca_topic_score_gemma":0.0002400428,"domain_scores_codex":[0.9993811,0.00002802766,0.0002357521,0.00008996167,0.0001703118,0.00009483236],"domain_scores_gemma":[0.9996638,0.000008823423,0.00009546709,0.00005618767,0.00006155601,0.000114217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.005595861,0.0003051089,0.3091696,0.00001021942,0.00005168659,0.0001196124,0.001917429,0.0001336314,0.1134689,0.000009306565,0.0017193,0.5674993],"study_design_scores_gemma":[0.3146668,0.03089993,0.5532717,0.0004405889,0.00002619328,0.0006573841,0.001285802,0.00004006967,0.03508365,0.001480295,0.061761,0.000386593],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930977,0.003350628,0.000219035,0.00297932,0.00008272439,0.00007323254,1.698302e-7,6.842915e-7,0.0001964942],"genre_scores_gemma":[0.9960783,0.002490428,0.0004756927,0.0004849598,0.0004101519,7.011635e-7,0.000007173665,0.000006098428,0.00004654988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5671127,"threshold_uncertainty_score":0.1889613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01036036072775383,"score_gpt":0.2617443459305269,"score_spread":0.2513839852027731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}