{"id":"W20865048","doi":"10.1593/neo.131434","title":"Regulation of Metformin Response by Breast Cancer Associated Gene 2","year":2013,"lang":"en","type":"article","venue":"Neoplasia","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre; Health Sciences Centre","funders":"National Cancer Institute; Barbara Ann Karmanos Cancer Institute","keywords":"AMPK; Ubiquitin ligase; Metformin; Protein kinase B; Protein kinase A; AMP-activated protein kinase; Cancer research; Phosphorylation; Small interfering RNA; Chemistry; Pharmacology; Cell biology; Ubiquitin; Medicine; Endocrinology; Biology; Biochemistry; Transfection; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000985706,0.0002391066,0.0002250691,0.0002315511,0.0001684684,0.0003233915,0.0001084112,0.0002318864,0.002030115],"category_scores_gemma":[0.0001176314,0.0001434306,0.0002421183,0.0002082453,0.0001420127,0.0001400166,0.0001819381,0.0005356603,0.0004868223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004099479,"about_ca_system_score_gemma":0.000213534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004981672,"about_ca_topic_score_gemma":0.0006596696,"domain_scores_codex":[0.9998605,0.00001661714,0.000009850008,0.00003989189,0.00003661013,0.00003647321],"domain_scores_gemma":[0.9999443,0.000009399811,0.00001598285,0.000005366798,0.0000103069,0.00001469776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002999555,0.00005385938,0.0004232635,0.00005664659,0.000008260218,0.00005141994,0.0000127419,0.00006679827,0.9964834,0.0001636106,0.0002399397,0.002139999],"study_design_scores_gemma":[0.00007342403,0.0002842339,0.02002678,0.000008643436,0.00002133933,0.0002092897,0.00004248002,0.002472494,0.9665418,0.00009014882,0.01021906,0.00001030484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852417,0.005204132,0.002653175,0.0004460677,0.000295755,0.000079208,0.001715334,0.0002219575,0.004142754],"genre_scores_gemma":[0.9830645,0.002751767,0.002883929,0.0004967503,0.00004342166,0.0001842297,0.002294014,0.0000603709,0.008220996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002030115,"threshold_uncertainty_score":0.006791353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003992270940037621,"score_gpt":0.2193595399705891,"score_spread":0.2153672690305515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}