{"id":"W2086533029","doi":"10.2165/00128072-200204040-00005","title":"Ethical Issues in Including Pediatric Cancer Patients in Drug Development Trials","year":2002,"lang":"en","type":"review","venue":"Pediatric Drugs","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Clinical trial; Modalities; Pediatric cancer; Intensive care medicine; Cancer; Drug trial; Pharmacotherapy; Cancer therapy; Pediatric oncology; Drug development; Cancer drugs; Informed consent; Alternative medicine; Drug; Psychiatry; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.07052871,0.000496992,0.002342804,0.001421509,0.0009543106,0.002787527,0.001437026,0.005900331,0.001552767],"category_scores_gemma":[0.08125092,0.0004795141,0.000979402,0.00203583,0.003523718,0.003063793,0.001767002,0.004518218,0.0003649392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001525725,"about_ca_system_score_gemma":0.01042734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007764039,"about_ca_topic_score_gemma":0.003118188,"domain_scores_codex":[0.9324388,0.05276195,0.006540999,0.0009409949,0.006799773,0.0005173663],"domain_scores_gemma":[0.8205633,0.1573386,0.01307388,0.002833898,0.005238279,0.0009520701],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003038433,0.00009893035,0.001906708,0.01947477,0.0002942196,0.001177081,0.001310363,0.0003036591,0.0006372465,0.02069746,0.02389358,0.9299021],"study_design_scores_gemma":[0.0004429677,0.0004248845,0.004859982,0.06495968,0.000949799,0.007821254,0.001595441,0.000226478,0.00153556,0.02139224,0.8957394,0.00005223874],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009511455,0.9717548,0.002557286,0.01920238,0.0006960887,0.0001229131,0.00002339397,0.000008890332,0.004683091],"genre_scores_gemma":[0.02294274,0.9313846,0.0131233,0.02824556,0.001859177,0.0007830237,0.00004346079,0.0000116071,0.001606516],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9294713,"threshold_uncertainty_score":0.3729959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2397918379949818,"score_gpt":0.4972663059799624,"score_spread":0.2574744679849806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}