{"id":"W2086544825","doi":"10.1128/jvi.80.3.1440-1450.2006","title":"Role of Helix P of the Human Cytomegalovirus DNA Polymerase in Resistance and Hypersusceptibility to the Antiviral Drug Foscarnet","year":2006,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Foscarnet; Biology; Polymerase; Mutant; Nucleotide; DNA polymerase; Mutation; Molecular biology; DNA; Virology; Human cytomegalovirus; Genetics; Virus; Gene; Ganciclovir","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002247686,0.0003438729,0.0002567006,0.0001965972,0.0001719273,0.0003070102,0.0002119128,0.0004280575,0.000756391],"category_scores_gemma":[0.0004893659,0.0001602655,0.0002528548,0.0001069468,0.0003185014,0.0003090132,0.0002489979,0.000266377,0.0004387487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003080965,"about_ca_system_score_gemma":0.000157457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003867283,"about_ca_topic_score_gemma":0.0002396716,"domain_scores_codex":[0.9998453,0.00004300526,0.0000161775,0.00002833191,0.00003814905,0.00002896622],"domain_scores_gemma":[0.999693,0.00006807411,0.0001060276,0.00002469976,0.00002920812,0.00007890389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005948314,0.00003409753,0.002785145,0.00003401617,0.00002048947,0.0006032872,0.00003681941,0.0006462486,0.9921894,0.0001430768,0.00003462399,0.002878094],"study_design_scores_gemma":[0.0001797178,0.001563845,0.05263312,0.00003475725,0.00006051808,0.002381632,0.0001368875,0.007444668,0.9333122,0.0005912377,0.00163374,0.00002771626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982319,0.000293541,0.0007952706,0.00004188754,0.000006027213,0.00001026822,0.0000301474,0.00003238337,0.0005585386],"genre_scores_gemma":[0.9995136,0.00006334774,0.0002200687,0.00001666609,0.000002222202,0.000004565737,0.00003359247,0.0000051877,0.0001407702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000756391,"threshold_uncertainty_score":0.002530336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01106831861707526,"score_gpt":0.2862364225020406,"score_spread":0.2751681038849653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}