{"id":"W2086555083","doi":"10.1210/jc.2003-030139","title":"Does a Combination Regimen of Thyroxine (T<sub>4</sub>) and 3,5,3′-Triiodothyronine Improve Depressive Symptoms Better Than T<sub>4</sub>Alone in Patients with Hypothyroidism? Results of a Double-Blind, Randomized, Controlled Trial","year":2003,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Thyroid Disorders and Treatments","field":"Medicine","cited_by":178,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; Hamilton Health Sciences; McMaster University","funders":"McMaster University","keywords":"Levothyroxine; Medicine; Triiodothyronine; Depression (economics); Regimen; Internal medicine; Placebo; Mood; Depressive symptoms; Randomized controlled trial; Thyroid; Pediatrics; Psychiatry; Anxiety","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003415416,0.0005044373,0.005198795,0.0005085458,0.0000795809,0.00001519222,0.0002840822,0.0003036342,0.000004159279],"category_scores_gemma":[0.003212153,0.0002288025,0.0007947516,0.0003353974,0.001100166,0.0002350787,0.00008913717,0.001002726,0.000001835203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000325321,"about_ca_system_score_gemma":0.0002802818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004121148,"about_ca_topic_score_gemma":0.00003012702,"domain_scores_codex":[0.9916243,0.002266471,0.004289279,0.0004373372,0.0008126827,0.0005699554],"domain_scores_gemma":[0.9899149,0.003641688,0.004757561,0.0006061555,0.0008376823,0.0002420312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9714969,0.004165293,0.01045523,0.00002342475,0.003276182,0.00004768385,0.0002742654,0.00001132674,0.006087967,0.0004507504,0.00005144815,0.00365952],"study_design_scores_gemma":[0.8952337,0.004602564,0.04035899,0.000112807,0.004196851,0.00005390285,0.0000667342,0.00001093738,0.05379121,0.001346547,0.00003022164,0.0001955515],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879642,0.004666731,0.00005595394,0.001580297,0.0007340968,0.004818689,0.0000268098,0.00001290782,0.0001402744],"genre_scores_gemma":[0.9951647,0.004056981,0.0001360396,0.0002125548,0.0002257637,0.0001094294,0.00001648232,0.0000475553,0.00003052019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07626323,"threshold_uncertainty_score":0.9330295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01347938651753591,"score_gpt":0.2839964814620206,"score_spread":0.2705170949444846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}