{"id":"W2086555274","doi":"10.1016/j.bmcl.2010.03.116","title":"Evaluation of amphiphilic aminoglycoside–peptide triazole conjugates as antibacterial agents","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Manitoba Health; University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Aminoglycoside; Kanamycin; Peptide; Neomycin; Antibacterial activity; Amphiphile; Combinatorial chemistry; Conjugate; Triazole; Antibacterial agent; Stereochemistry; Biochemistry; Antibiotics; Bacteria; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004134572,0.0003265886,0.000328645,0.0002341336,0.0001886039,0.0002658153,0.0001760262,0.0003615308,0.0009818939],"category_scores_gemma":[0.0003458378,0.0001768655,0.0001934355,0.0002543911,0.000179952,0.000247289,0.0001701824,0.0002582414,0.0001894338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002275952,"about_ca_system_score_gemma":0.0002077137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005326332,"about_ca_topic_score_gemma":0.0007387277,"domain_scores_codex":[0.999694,0.0001067806,0.00002372507,0.00003474986,0.0000823982,0.00005842512],"domain_scores_gemma":[0.9998336,0.0000465046,0.00003700213,0.00001086147,0.00003717977,0.00003493556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003009484,0.00007431235,0.00006325751,0.00003492555,0.000004901355,0.00003991272,0.00001844564,0.0001195491,0.9980614,0.00003335863,0.00001525429,0.001233835],"study_design_scores_gemma":[0.0000322663,0.001612375,0.0005868636,0.000002568019,0.00001803163,0.0000623743,0.000009389973,0.0005808188,0.9966426,0.000004875656,0.0004444454,0.000003363841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974737,0.0008128073,0.0008615783,0.00002432586,0.00001213113,0.00005441809,0.00004852316,0.00001983557,0.0006926311],"genre_scores_gemma":[0.9968287,0.0006895926,0.001448074,0.00001559567,0.000007867591,0.00003736404,0.00008564139,0.000008456645,0.0008786655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009818939,"threshold_uncertainty_score":0.003284752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0252254763141224,"score_gpt":0.286655162709797,"score_spread":0.2614296863956746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}