{"id":"W2086569396","doi":"10.1371/journal.pone.0092394","title":"The Anti-Hypercholesterolemic Effect of Low p53 Expression Protects Vascular Endothelial Function in Mice","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Canadian Institutes of Health Research; Institut de Cardiologie de Montréal","keywords":"Endocrinology; Internal medicine; Prostacyclin; Endothelium; Endothelial dysfunction; Lysophosphatidic acid; Nitric oxide; Nitric Oxide Synthase Type III; Inflammation; Chemistry; Enos; Cholesterol; Endogeny; Vasoprotective; Biology; Nitric oxide synthase; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002266776,0.0005861857,0.000361029,0.0005271517,0.0002495026,0.0003839742,0.0003640576,0.0005659269,0.001574209],"category_scores_gemma":[0.0001457205,0.0003237052,0.0003835272,0.0002078175,0.0004687711,0.0003634825,0.0002291798,0.0009106806,0.0004320516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002532177,"about_ca_system_score_gemma":0.0002052013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004174948,"about_ca_topic_score_gemma":0.0005583956,"domain_scores_codex":[0.9998062,0.0000255926,0.00002539795,0.00005488159,0.00003576605,0.00005215367],"domain_scores_gemma":[0.9997169,0.00001874572,0.000121165,0.00004151263,0.00002713196,0.0000743546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007380077,0.0001509676,0.0003112866,0.00004482559,0.00001160573,0.00006763764,0.00001312598,0.0000369818,0.9970207,0.00008879565,0.00005031329,0.001465704],"study_design_scores_gemma":[0.0002645138,0.003449359,0.01292484,0.00003224091,0.00009455973,0.0006069674,0.0000615832,0.000872474,0.9791261,0.0001792552,0.002375463,0.00001272415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950635,0.001133221,0.002285696,0.0001956936,0.00004688545,0.00003007931,0.0004244138,0.0001823428,0.0006381656],"genre_scores_gemma":[0.9906842,0.001566258,0.002550793,0.0001516448,0.00003575251,0.0001140592,0.000687527,0.00005813831,0.004151755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001574209,"threshold_uncertainty_score":0.005266309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00731376656450379,"score_gpt":0.1989482442211089,"score_spread":0.1916344776566051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}