{"id":"W2086586493","doi":"10.1021/jp5086813","title":"Activation Kinetics of Zipper Molecular Beacons","year":2014,"lang":"en","type":"article","venue":"The Journal of Physical Chemistry B","topic":"Advanced Biosensing Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Grand River Hospital; University of Waterloo; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"Zipper; Leucine zipper; Cleavage (geology); Biophysics; Chemistry; Proteases; Cleave; Matrix metalloproteinase; Arginine; Molecular beacon; Biochemistry; Transcription factor; Amino acid; Biology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004987761,0.0003398076,0.0002962953,0.000233811,0.0001530236,0.0004585854,0.0005748497,0.0004469455,0.003539911],"category_scores_gemma":[0.001393718,0.0002269014,0.000222876,0.0002249386,0.0003605708,0.000598411,0.000244473,0.0008159998,0.0007553329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006535863,"about_ca_system_score_gemma":0.0002128374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005236664,"about_ca_topic_score_gemma":0.0002372954,"domain_scores_codex":[0.9996603,0.00003673814,0.00001065727,0.0001012854,0.00009252453,0.00009861254],"domain_scores_gemma":[0.9994028,0.0003061454,0.00009919723,0.00003237668,0.000103376,0.00005608012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000524024,0.00006754522,0.000758293,0.0001061116,0.00002123678,0.00008290791,0.0002849858,0.006969835,0.9797062,0.002940179,0.0004326058,0.008106085],"study_design_scores_gemma":[0.00002831009,0.0003895314,0.0009914244,0.000007753843,0.000008418853,0.00005124985,0.00005171998,0.0527784,0.9430393,0.0004478479,0.002185882,0.00002017951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731962,0.0007043508,0.02253094,0.0001288616,0.00003790452,0.00005852174,0.0002138049,0.0003466495,0.002782658],"genre_scores_gemma":[0.9941748,0.0002441765,0.003532469,0.00004866114,0.000005206922,0.00004187642,0.0001947686,0.00004287824,0.001715171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003539911,"threshold_uncertainty_score":0.01184219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004940837304002381,"score_gpt":0.2549748606805678,"score_spread":0.2500340233765655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}