{"id":"W2086586493","doi":"10.1021/jp5086813","title":"Activation Kinetics of Zipper Molecular Beacons","year":2014,"lang":"en","type":"article","venue":"The Journal of Physical Chemistry B","topic":"Advanced Biosensing Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Grand River Hospital; University of Waterloo; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"Zipper; Leucine zipper; Cleavage (geology); Biophysics; Chemistry; Proteases; Cleave; Matrix metalloproteinase; Arginine; Molecular beacon; Biochemistry; Transcription factor; Amino acid; Biology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008174619,0.00006754467,0.00009890546,0.000005298288,0.00001892905,0.000002968006,0.0001669375,0.00004329687,0.000002000813],"category_scores_gemma":[0.00007601169,0.00004612688,0.00008598507,0.00004757882,0.00009432426,0.000001971866,0.00004071174,0.00009541705,3.319197e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005582447,"about_ca_system_score_gemma":0.00001132639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":5.721108e-7,"about_ca_topic_score_gemma":4.565542e-8,"domain_scores_codex":[0.9996026,0.00001984668,0.0001479734,0.00005718035,0.0001013728,0.00007102585],"domain_scores_gemma":[0.9993798,0.00002546704,0.0002121782,0.0002142293,0.0001360372,0.00003232887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002317601,0.00007255466,0.000003599431,0.000008552714,0.00001488888,8.273768e-8,0.00001186227,0.0002625266,0.9982976,0.0001400178,0.0002231372,0.0009419894],"study_design_scores_gemma":[0.0001170368,0.0001354317,0.00003996358,0.00001562428,0.00002611036,0.00001277841,0.00001482363,0.0001190094,0.9930807,0.001435243,0.004951351,0.00005189176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.933587,0.00002246708,0.06517797,0.0003320961,0.000005659575,0.0000321198,0.000002164695,0.000003193232,0.0008373161],"genre_scores_gemma":[0.9980567,0.00001116087,0.001556069,0.00006963264,0.0002428418,6.61107e-7,0.000005451921,0.000008525707,0.00004899467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06446965,"threshold_uncertainty_score":0.1881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004940837304002381,"score_gpt":0.2549748606805678,"score_spread":0.2500340233765655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}